1. Biorefinery of the Future ConVergInce / Lee Enterprises Consulting
ABLC Washington, DC. March 2018
Joel A. Stone
ConVergInce Advisers
We did not inherit the earth from our parents. We are borrowing it from our children.

2. Transition Biofuels to Renewable Chemicals
The birth of the industry began in various forms from biofuels
Ethanol
Butanol
Bio-diesel
Renewable diesel
Farnesene
Algae oils
The move to chemicals was encouraged by the USDA with the publication of the 2004 DOE/NREL report on the top 12 biochemicals
Many of these chemicals were basic building blocks and commodity related
The evaluation was completed using agricultural based feedstocks

3. BioRefinery Options Biofuels to Renewable Chemicals
The top 12 chemicals included:
Four Carbon 1,4-Diacids (Succinic, Fumaric, and Malic)
2,5-Furan dicarboxylic acid (FDCA)
3-Hydroxy propionic acid (3-HPA)
Aspartic acid
Glucaric acid
Glutamic acid
Itaconic acid
Levulinic acid
Hydroxybutyrolactone
Glycerol
Sorbitol (Alcohol Sugar of Glucose)
Xylitol/arabinitol (Sugar alcohols from xylose and arabinose)
For a copy of the newly updated report:

4. Renewable Chemicals $450 Billion Specialties
Cosmetics 2%
Specialty Polymers %
Global chemical market 2014: $5.4 Trillion
Adhesives & Sealants 2%
Other %
Printing Inks 3%
Construction Chemicals %
Feed Additives 3%
I&I Cleaners %
Plastic Additives %
Electronic Chemicals %
Food Additives %
Oilfield %
Surfactants %
Catalysts 5%
Specialty Coatings %
Flavors/ Fragrances 6%
Source
2014:
Water Soluble Polymers 6%

5. Future for Biorefining The Need to Scale

6. Strategies for Growth Experience Matters
Strategies for de-risking, commercialization & growth require:
Solid laboratory and bench chemistry development.
Pilot developments and Pilot replication testing.
Demonstration plant operation at 1/25th to 1/50th commercial scale.
Intermediate capital budgeting including an FEL3.
A well thought-out and planned Engineering, Procurement and Construction program including risk management focus.
A clear commissioning and startup plan.
Lessons learned: Why have there been many failures?
Skipping proper time allotments or short cutting lab, pilot, and demo plans.
Shortcutting the capital budget with unrealistic FEL3 designs.
Inability to be fully funded to reach the objective.
Understanding the importance of product quality and differentiation versus predecessor products.
What are the customer needs and priorities?

7. Filling a Gap Contract Fermentation and Recovery Facilities
Risk Management
Scale up, demonstration, and commercialization.
Use lessons learned to calculate approaches to stay on plan.
An experienced team to guide a project, technology, or business
Commercial experience.
Sound knowledge in latest developments.
Planning
Set up milestones across the enterprise and revise as we learn.
Be adaptable in setting goals.
Collaborations
Teamwork that is flexible and looks for successful pathway.
Quality Delivery
The client deserves a first rate package of deliverables.

8. Flexible Biorefining Approach Accelerating to Scale
Contract fermentation and recovery offers a capital light approach while leveraging existing infrastructure in place. A pathway for Industrial Biotech. Functions and resources to consider:
PURE WATER
ELECTRICITY
CHILLED WATER
NATURAL GAS
STEAM
TRANSPORTATION
UNIVERSITIES
SYNTHESIS
RECOVERY
Access to existing resources and infrastructure
TECHNICAL EXPERTISE

9. Collaboration Fulfilling the Business Needs
Value creation
Accelerate the rate of execution.
Increase value with a joint effort that offers cost reduction.
Focus on scale and tech transfer.
Specialty and Performance chemicals
Get closer to the customer and ultimately the consumer.
Value of a product is in the performance and application that meets a customers need.
How does synthetic biology or catalysis fit.
Fairness
Balance between client and consultant and facility is absolutely necessary.
There is one winner and that is the collaboration to meet client product needs.
LEC collaborator TEAMS fill in the gaps for the Client.

10. Thank you
Collaborative Expert Advice
Outcome: Success Stories