1. Ribosome Rescue and Protein Quality Control in Concert
Tarek Hilal, Christian M.T. Spahn 
Molecular Cell 
Volume 57, Issue 3, Pages (February 2015)
DOI: /j.molcel
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 Scheme of the Ribosomal Quality Control
Translation of a non-stop mRNA (orange) causes ribosomal stalling. mRNA surveillance mechanisms involving the rescue factors Pelota (Dom34 in yeast) and Hbs1 sense the abnormal pausing, ABCE1 promotes splitting of the 80S ribosome into subunits. After binding of the ribosome quality control factor NEMF (Tae2 in yeast, also named Rqc2) (pink) to the 60S-RNC (light blue), spontaneous reassociation of the subunits into 80S is prevented and the 60S-RQC is stabilized. Degradation of the mRNA as well as re-initiation of translation by the 40S subunit (yellow) can occur. The E3-Ligase Listerin (Ltn1 in yeast) (orange) can join the stabilized 60S-RQC and position the catalytic RING-domain (black circle) close to the nascent peptide chain (purple). Addition of ubiquitin chains (red squares) to the nascent peptide target it for proteasomal degradation.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2015 Elsevier Inc. Terms and Conditions