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Skin Explant Model of Human Graft-versus-Host Disease: Prediction of Clinical Outcome and Correlation with Biological Risk Factors  Xiao-nong Wang, Matthew.

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Presentation on theme: "Skin Explant Model of Human Graft-versus-Host Disease: Prediction of Clinical Outcome and Correlation with Biological Risk Factors  Xiao-nong Wang, Matthew."— Presentation transcript:

1 Skin Explant Model of Human Graft-versus-Host Disease: Prediction of Clinical Outcome and Correlation with Biological Risk Factors  Xiao-nong Wang, Matthew Collin, Lisbet Sviland, Scott Marshall, Graham Jackson, Ute Schulz, Ernst Holler, Sigrid Karrer, Hildegard Greinix, Fariborz Elahi, Ilona Hromadnikova, A.M. Dickinson  Biology of Blood and Marrow Transplantation  Volume 12, Issue 2, Pages (February 2006) DOI: /j.bbmt Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Histopathologic changes for different grades of skin GVHR. A, Grade I skin GVHR showing very mild vacuolization of epidermal cells. B, Grade II skin GVHR showing diffuse vacuolization of epidermal cells. C, Grade III skin GVHR showing cleft formation between the epidermis and dermis caused by confluent vacuolar damage to basal keratinocytes. D, Grade IV skin GVHR showing the complete separation of the epidermis and dermis. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Association of skin GVHR grade with HLA matching status, sex combinations, and patient age. In Figure 2A, a, b, and c represent HLA-matched related, HLA-matched unrelated, and HLA-unmatched unrelated allopairs, respectively. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

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