1. HS 4160 Critical Scientific Analysis
Week 8: Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation Depends on Cytogenetic Risk for Acute Myeloid Leukemia in First Disease Remission
HS 4160 Critical Scientific Analysis

2. True.
False.
From my search outside of this paper, I understand that allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a procedure in which a person receives blood-forming stem cells from a genetically similar, but not identical, donor such as sister or brother.

3. True.
False.
From my search outside of this paper, I understand that autologus hematopoietic stem cell transplantation (auto-HSCT) is a procedure in which a person receives his/her own blood-forming stem cells after high-dose chemotherapy with or without radiotherapy with the intention of eradicating his/her malignant cell population.

4. What is the objective(s) of the study?
To identify the karyotype of AML patients who received allo-HSCT and were in first complete remission.
To identify the efficacy of allo-HSCT for patients with AML in second complete remission.
To identify the efficacy of allo-HSCT for patients with AML in first complete remission.
To identify the karyotype of AML patients who received allo-HSCT and were in second complete remission.

5. Which of the following regarding to AML and allo-HSCT is NOT true?
Efficacy comparison between allo-HSCT and auto-HSCT is usually biased due to many uncontrolled factors.
Allo-HSCT is less effective than auto-HSCT.
More than 70% young AML patients could achieve complete remission.
Karyotyping is the most relevant prognostic marker for AML.

6. All of the following were inclusion criteria EXCEPT:
Original paper in English.
Studies dealing only with children.
Used overall survival as outcome.
Published between 1995 and 2003.

7. Based on the result from table 1, _____ overall survival hazard ratio subgroup comparison were significant. 4 3 2 1

8. Which statistic software was used for this study?
SAS.
SPSS.
STATA.
CMA.

9. Favorable. Intermediate. Poor. Unknown.
inv(16)/t(16;16)/del(16q) was considered as ________ by all three groups according to table 2?
Favorable.
Intermediate.
Poor.
Unknown.

10. study ID 2-1. study ID 3-4. study ID 4-4. study ID 5-4.
Which of the following study carried more weight when compared to the rest based on Figure 1?
study ID 2-1.
study ID 3-4.
study ID 4-4.
study ID 5-4.

11. This chromosome abnormality is associated with poor outcome according to table 2.
del(5q).
t(15;17).
inv(16).