1. Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy 
Arturo R. Palomares, M.Sc., Ana M. Lendínez-Ramírez, M.Sc., Beatriz Pérez-Nevot, M.Sc., Miriam Cortés-Rodríguez, M.Sc., Francisco Martínez, Ph.D., Nicolás Garrido, Ph.D., Maximiliano Ruiz-Galdón, M.D., Armando Reyes-Engel, M.D. 
Fertility and Sterility 
Volume 99, Issue 7, Pages e2 (June 2013)
DOI: /j.fertnstert
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

2. Supplemental Figure 1
Hypothesized scheme representing serotonin (5-HT) interaction with different genes included in the study. Monoamine oxydase A (MAO-A) degrading activity of 5-HT would remove it in 5-hydroxyndolacetic acid (5-HIAA). Tryptophan can derive in 5-HT by tryptophan hydroxylase 1 (TPH1) and aromatic amino acid decarboxylase (AADC) enzymes. The 5-HT receptors 2A and 2C activate phospholipase C (PLC) through G-protein (Gq) coupled subunit that promotes transformation of phosphatidylinositol 4,5-bisphosphate (PIP2) in diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). These second messengers activate protein kinase C (PKC), which in time may activate the extracellular signal-regulated kinases (ERK). 5-HT1A G-protein (Gi) coupled subunit inhibits the formation of cyclic adenylate monophosphate (cAMP) by adenylate cyclase (AC), which also modify ERK activity in a different way.
Fertility and Sterility  , e2DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions