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Disparities in CRC in Hispanics

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Presentation on theme: "Disparities in CRC in Hispanics"— Presentation transcript:

1 Epidemiologic, Environmental & Molecular Disparities in GI Cancer Among Hispanics

2 Disparities in CRC in Hispanics

3 Cancer Health Disparities

4 Population Geographical Distributions by Race/Ethnicity

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6 Colorectal Cancer (2012)

7 20 Highest Countries in the Americas

8 Age-Adjusted. Incidence Rates of Colorectal Cancer in U. S
Age-Adjusted* Incidence Rates of Colorectal Cancer in U.S. by sex and Race/Ethnicity ( )

9 Age-Adjusted. Mortality Rates from Colorectal Cancer in U. S
Age-Adjusted* Mortality Rates from Colorectal Cancer in U.S. by sex and Race/Ethnicity

10 CRC Incidence Increases for Hispanics when comparing rates in their Native country to US rates

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13 5-Year Survivorship According to Age at Diagnosis in US Hispanics (2005-2010)

14 Disparities in CRC in Hispanics

15 Environment & Colorectal Carcinogenesis

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18 Gut Microbiome & Colon Cancer

19 Phylogenic Differences in Gut Microbiome Composition between African Americans (AA) and North African (using 16S-rRNA)

20 Pro-inflammatory Environment with Lower SSF & Higher Bile Acids in African Americans

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23 Gut Microbiome --- Colorectal Neoplasia

24 Role of Gut Bacterial Genes

25 Higher Prevalence of Genotoxic Bacterial Toxins in Stool of Patients with CRN

26 Disparities in CRC in Hispanics

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30 Molecular Characterization of Colorectal Cancer in Hispanics

31 Molecular Characterization of CRC tumors of Puerto Rican Hispanics

32 Hereditary Contribution to CRC

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34 GWAS Hits Hispanics Associated with CRC

35 GWAS Hits in Hispanics Associated with CRC

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38 Ancestry Proportion Hispanics from PR and Colon CFR

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40 Genetic ancestry and CRC risk in PRH

41 Nutrition, Genetic Ancestry and CRN risk in PRH

42 Summary Disparities

43 Picture of Screening

44 Prevalence of Colorectal Cancer Screening by Ethnicity in U. S
Prevalence of Colorectal Cancer Screening by Ethnicity in U.S.* and PR, 2012

45 Administrative Order 334

46 International CRC Screening Programs International CRC Screening Network

47 Colon Cancer Dress in Blue Day March 4, 2016

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49 GI GENE TEAM (Gastrointestinal Genetic Epidemiology Network)


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