1. Diapact® CRRT Technical Training
November 18
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2. Nine Types Of Therapies For The Patient One Hand Operation
Universal tool for a wide range of therapies
4 continuous therapies:
SCUF
CVVH
CVVHD
CVVHFD
3 intermittent therapies: HF HD
HFD
2 plasma therapies:
PEX
PAP
November 18
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3. 1. Slow Continous Ultrafiltration
Continous Therapies
1. Slow Continous Ultrafiltration
November 18
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4. Continous Therapies 2. CVV Hemofiltration November 18
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5. Continous Therapies 3. CVV Hemodialysis November 18
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6. 4. CVV High-Flux Dialysis
Continous Therapies
4. CVV High-Flux Dialysis
November 18
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7. CVVHFD The Principle Of Substitution By Backfiltration
November 18
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8. Intermittend Therapies 1. Hemofiltration
November 18
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9. Intermittend Therapies 2. Hemodialysis
November 18
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10. Intermittend Therapies 3. High-Flux Dialysis
November 18
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11. Plasma Therapies 1. Plasma Exchange November 18
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12. 2. Plasma Adsorbtion/Perfusion
Plasma Therapies
2. Plasma Adsorbtion/Perfusion
November 18
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13. Special Functions therapy change during treatment
dilution change (postdilution « predilution)
flexible adjustment of parameters
ratio monitoring of filtrate flow vs. blood flow
automatic substitution-flow reduction in case of UF problems
re-calibration of blood leak detector
ramping of the pumps
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

14. Special Functions bag movement function safe exchange of bags
bag change volume
automatic temporary blood flow reduction in case of pressure problems
end of therapy on intermittent HF
different sounds for alarms and messages
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

15. Hidden Functions
Hidden functions are selected by pushing the buttons V, BE and an additional button simultaniously:
BP + display backlight brighter
BP - display backlight dimm
EQ TSM mode
up contrast up
down contrast down
SC language selection
5 skip priming (if the function is enabled)
6 service overview
Enter Reset
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

16. General Information
Diapact® CRRT is a system for extracorporeal blood treatment,
especially for the use in emergency situations where a steady supply
of purified water is not available.
The simplified user interface and intelligent software incl. full
automatic filling and priming and automatic level regulation help to
keep personnel requirements to a minimum.
The Diapact® CRRT has three pumps and an electronic weighing
system which constantly controls and monitors the patient ‘s fluid
balance.
A trouble-free balancing increases the efficiency of the treatment
and results in advancement of cost-value ratio.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

17. General Information
Because the Diapact® CRRT works with sterile solutions in bags and a
complete set of disposable tubes, no disinfection procedure is required
after the treatment. The choice of the filter leaves to the user.
The solutions are wormed by the integrated plate warmer.
Apart from the continuous treatment of patients in acute need of
dialysis, the Diapact® CRRT system can be used to carry out
intermittent hemofiltration and high-flux dialysis treatments in
patients with chronic renal disease.
The default parameters of each therapy (e.g. pressure limits) are
changeable at any time.
With this system, diffuse and convective transport can be combined by
using highly permeable membranes.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

18. General Information
The Diapact® CRRT system monitors the filtration and back filtration
mechanism in the filter. As a result, the volume of substitution solution
required is reduced.
The single load cell of Diapact® CRRT enabled a recirculation of
solution for more effective using of dialysate.
To complete the therapy choice of Diapact® CRRT, Plasmaexchange as
well as Plasma-Adsorption-Perfusion are available for the user with
this system.
Diapact® CRRT System can be supplemented with Option Perfusor
Interface for flexible anticoagulation.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

19. Therapy Change
With SETUP CHANGE the user can change from CVVH or HF to
CVVHD, CVVHFD, HD or HFD as well as from CVVHD, CVVHFD, HD or
HFD to CVVH or HF during therapy.
For this activate the function THERPY END in menu selection and
after that the function SETUP CHANGE.
Follow the instructions of the guideline in the display and confirm the
THERAPY EXCHANGE by activating and EQ confirming.
All therapy data survive after therapy exchange.
To continue the therapy the user has simply to adapt the blood flow
and to confirm the blood leak calibration.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

20. Dilution Change
With SET UP CHANGE the user can do a dilution exchange during
therapy (from pre-dilution to post-dilution or the other way).
For this activate the function THERPY END in menu selection and
after that the function SETUP CHANGE.
Follow the instructions of the guideline in the display and following
activate or deactivate PRE-DILUTION.
Deactivate SET UP CHANGE to return back to Parameter overview.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

21. Parameter Setting During Therapy 1/2
Each of the main parameters (UF-volume/plasma balance, UF-
rate/plasma balance rate, therapy time, sub volume/ dialysate volume/
plasma volume, sub flow/dialysate flow/plasma flow) can be set
independently of the others.
Automatically changed safety-relevant parameters (highlighted in
black) has to be confirmed with EQ. Flashing parameters indicate a
change but do not have to be confirmed separately.
NOTE
The zero setting of the volumes or of the therapy time in all intermittent
therapies (HF/HD/HFD/PEX/PAP) only causes the switching from
volume control to rate control. That means that a zero setting of the
weight reduction (e.g. UF-rate), of the substitution or the dialysate
can only be done by changing the rate.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

22. Parameter Setting During Therapy 2/2
Intermittent Therapy
PEX
PAP
A change in the flow rate
automatically results in a
change in volumes.
A change in the volumes
change in the flow rates.
A change in the therapy time automatically results in a change in the flow rates.
A change in the sub flow
automatically results in a change
in the therapy time and the plasma
balance rate (if set).
A change in the plasma balance
rate automatically results in a
change in the plasma balance
volume.
A change in the sub volume
volume automatically results in a
change in the plasma balance rate.
A change in the therapy time
in the flow rates.
A change in the plasma flow
change in the therapy.
A change in the plasma
volume automatically results
in a change in the therapy
time.
change in the plasma flow.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

23. Ratio Blood Flow/Filtrate
If the ratio of blood flow to filtrate exceeds 25 % in continuous or
intermittent therapies (postdilution) or 35 % in plasma therapies, the
user will receive a warning.
If this ratio exceeds 40 % during continuous or intermittent therapies
(postdilution) or 50% during plasma therapies, an alarm will be given
to the user and the balance pumps will stop.
This ensures that the blood retains the necessary viscosity.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

24. Automatic Substitution Flow Reduction
Automatic substitution flow reduction is an automatic parameter
adaptation to the current filter state undertaken by the system.
If the filtrate flow cannot be achieved, the following control
mechanism for the filtrate pressure PD2 sets in:
If PD2 pressure reaches a value 20 mm Hg above the set PD2 min.
value, the substitution flow will automatically be reduced as a
function of the filter state.
If the PD2 values reaches the set PD2 min. value, the user will be
given the additional warning “Clotting danger”.
If the PD2 value exceeds the set PD2 min. by over 50 mmHg, the user
will be given the alarm “Clotting danger 914” with the instruction to
reduce substitution or to increase the blood flow. The balance pumps
will remain stopped while the blood pump continues to operate.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

25. BLD Leakage/Recalibration
In the event of a non acknowledgable blood leakage alarm, the user
has to check the filter for a possible filter rupture.
To carry out precise examination of the filter, the user can take a
filtrate sample containing at least 2 ml at the sample collection point
in filtrate tube 2 and examine it. If no blood constituents are found in
the filtrate sample, the blood leakage detector can be recalibrated as
follows (example: rise in bilirubin):
· Select “THERAPY END“ in the menu selection. Confirm with
· and EQ.
· In the new menu selection, select “BLOOD LEAKAGE
CALIBRATION”. Confirm with
· Select “Back to therapy“. Confirm with
· Raise blood flow to initial value blood flow.
· Start THERAPY.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

26. Ramping
This function prevents the build-up of a secondary membrane on the
membrane as a result of underpressure created by jerky pump starts.
At the start of therapy, after every stop of the blood pump, and after
some parameter changes in HF/PEX/PAP, the balance pumps run at
reduced speed.
To guarantee that the system does not fall below the minimum
substitution volume, the flow is automatically increased slightly
during the therapy.
The raising of the flow, as well as the continuous raising of the flow,
depends on the frequency of RAMPING.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

27. Bag Movement Function
To avoid superfluous alarms and the resulting pump standstill, the
Diapact® CRRT has a function which is actuated by slight movements
of the unit during therapy.
When this function is actuated, the balance pumps stop without an
alarm and start again automatically when the initial weight (i.e. the
weight before the movement of the unit or bag) is reached again.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

28. Bag Change
It is possible to change the bag before the bag-change volume has
been achieved at any time during the therapy.
Activate the function BAG CHANGE in the MENU SELECTION.
The balance pumps will stop. The bag can now be changed without
disturbing the scale and without an alarm. To start the therapy again,
deactivate only the function BAG CHANGE by pressing the enter
button.
The balance pumps will start.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

29. Bag Change Volume 1/2
With the function “bag change volume”, the user can define the
volume of fluid at which the bag on the scale is to be changed. At a
bag volume (sub/dialysate or UF) of “zero“, this function is not active
and monitoring of the sub/dialysate bag is carried out via the air
detector (AD):
It is possible to select this function for the sub bag volume or for the
UF-bag volume. A selection made by the user in the positive range in
the parameter settings results in a sub bag volume, while a selection
in the negative range results in a UF bag volume.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

30. Bag Change Volume 2/2 Example 1: 2 bags á 4.5 l substitution
entry: sub bag volume: 9 l – 100 ml = 8.9 l
Example 2: 2 UF bags á 7 l collecting volume
entry: UF bag volume: -14 l
To change from sub bag volume to UF bag volume or the other way
during therapy the user has to confirm the zero at first by pressing
due to safety reasons. At first time parameter setting the zero is
default.
On reaching of the setted volume the alarm “bag volume is over”
(1020) occurs and the bags must be changed. Follow the instructions
on the display.
NOTE
By using the sub bag volume we recommend to adjust the volume
directly at the beginning of priming to calculate also the delivered
sub volume during priming.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

31. Automatic Temporary Reduction Of Blood Flow
When PA min is reached, blood flow automatically drops briefly to 60
ml/min. to prevent standstill of the blood pump caused by movement
of the patient.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

32. Therapy End During Intermittent HF
1. Therapy end when the preselected treatment time has been reached
The unit issues an alarm (balance-side alarm tone) and displays the
message “Therapy time reached“ in the alarm field. The therapy is
automatically interrupted.
2. Therapy end when the preselected substitution volume has been reached
message "Substitution volume reached” in the alarm field. The
therapy is automatically interrupted.
3. Therapy end when the preselected UF-volume has been reached
message "UF volume reached” in the alarm field. The therapy is
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

33. Therapy End
THERAPY END is carried out in the same manner for all of the
therapy-ending modes. Now the field “THERAPY END” should be
selected with the cursor. Therapy end is confirmed with “Enter” and
the EQ button.
The message “THERAPY END – blood return” appears in the status line.
The blood pump should be stopped. The arterial line should be
disconnected and connected to a 250ml saline bag. Then start up the
blood pump and reduce the flow to 100 ml/min. When the saline bag
is empty, stop the blood pump and note the important data (e.g.
substitution volume, UF volume, etc.) Now disconnect the venous line
from the patient and the unit can be switched off.
The data are preserved for 4 houres; they can be called up by
switching the unit on again.
November 18
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This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

34. Alarm And Message Tones
For better identification of the alarm situation, the Diapact® CRRT
distinguishes between
· blood-side alarms
· balance-side alarms and
· message tones
Depending on the urgency, blood-side alarms are displayed with a continuous
tone and balance-side alarms with an intermittent tone; message tones are
displayed acoustically every 30 seconds.
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.

35. The All-In-One Principle When It Matters, Everything Is Prepared
Versatility is reassuring
easy to operate
versatile because fully equipped
available anytime
ready in an instant
mobile and independent of water sources
versatile therapy forms integrated
ideal for high volume therapies
economical, saves time and effort
November 18
Training document, no update service
This document may not be copied, partly or whole, or made be accessible to third parties without our permission and remains the property of B. Braun Medizintechnologie GmbH with all rights.