1. Calling All Hosts: Bacterial Communication In Situ
Jessica L. Cleary, Alanna R. Condren, Katherine E. Zink, Laura M. Sanchez 
Chem 
Volume 2, Issue 3, Pages (March 2017)
DOI: /j.chempr
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2. Chem 2017 2, DOI: ( /j.chempr )
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3. Figure 1
Transient, Commensal, and Pathogenic Bacteria Can Reside Both Separately or in Combination within a Host
To date, most studies have inferred relationships on the basis of metagenomic surveys of the microbes in or on a host (A), but as further chemical information is learned, a direct inference can be made about the host systems (B).
Chem 2017 2, DOI: ( /j.chempr )
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4. Figure 2
Molecular Structures of Compounds Involved in Host-Pathogen Interactions that Elicit Responses according to Environmental Changes
Chem 2017 2, DOI: ( /j.chempr )
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5. Figure 3
A Vast Amount of Unknown Chemistry Is Involved in Gene Regulation of V. cholerae, as Depicted by the Lack of Identification of Protein in the Genome
MALDI-TOF MS is a tool that can be used to work toward identifying the unknown chemistry and aid in determining the biological function of genes in these species.
(A) Gene cluster analysis of V. cholerae (GenBank: NC_00205 [chromosome I] and NC_ [chromosome II]) with data collected and annotated by antiSMASH and the Kyoto Encyclopedia of Genes and Genomes (KEGG).
(B) Imaging mass spectrometry data collected by MALDI-TOF MS. P. aeruginosa was analyzed in situ and treated with a non-lethal biofilm inhibitor for visualization of the spatial distribution of small molecules regulated before and after exposure to treatment.
Chem 2017 2, DOI: ( /j.chempr )
Copyright © 2017 Elsevier Inc. Terms and Conditions

6. Figure 4
Molecular Structures Involved in the Establishment and Maintenance of Symbiotic Relationships between Microbes and Animals
Chem 2017 2, DOI: ( /j.chempr )
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7. Figure 5
The Euprymna-Vibrio Symbiosis Serves as a Simple System within which to Relate Genetics to Unknown Chemistry
(A) An illustration of the winnowing process of Euprymna scolopes that selects for Vibrio fischeri. The limb-like winnowing structures on the squid mantle secrete a mucus that attracts the bacterial symbiont into the crypts of the internal light organ. The bacterium makes up 0.02% of the population in the surrounding sea water but 100% of the population in the crypts of the light organ.
(B) Peptidoglycan (6) and PLA (5) are two mucosal molecules that attract the bacterial symbiont during acquisition. OHHL (7) is an autoinducer that activates the light-producing LuxR pathway inside the light organ to activate counterillumination.
(C) One-third of the genes in the genome of Vibrio fischeri (strain ES114 [GenBank: NC_ ]) have no observed or hypothesized function.104 Many of these are likely to be small molecules or specialized secondary metabolites.
Chem 2017 2, DOI: ( /j.chempr )
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8. Figure 6
Molecules Transiently Involved in Human and Bacterial Interactions
Chem 2017 2, DOI: ( /j.chempr )
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9. Figure 7
Using Mass Spectrometry Techniques, We Can Identify Molecules Produced by Bacterial Communities Found in Cheese Rinds
Microbes that are normally found on naturally aged cheese rinds were cultured and extracted. After prioritization by mass spectrometry experiments, molecules were purified and further analyzed by mass spectrometry. Tandem mass spectrometry (MS2) of prioritized (MS1) signals revealed the molecular fragmentation for the purpose of identifying novel molecules, as well as dereplication. Direct analysis of cheese rinds with mass spectrometry tools can aid comparison of laboratory cultures with cheese rinds. Cheese rind picture reprinted from Wolfe et al.69
Chem 2017 2, DOI: ( /j.chempr )
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