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Volume 66, Issue 4, Pages (October 2004)

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Presentation on theme: "Volume 66, Issue 4, Pages (October 2004)"— Presentation transcript:

1 Volume 66, Issue 4, Pages 1578-1588 (October 2004)
Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure  H. David Humes, William F. Weitzel, Robert H. Bartlett, Fresca C. Swaniker, Emil P. Paganini, Jack R. Luderer, Joseph Sobota  Kidney International  Volume 66, Issue 4, Pages (October 2004) DOI: /j x Copyright © 2004 International Society of Nephrology Terms and Conditions

2 Figure 1 Schematic of the extracorporeal circuit for the perfusion of the bioartificial kidney. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

3 Figure 2 Plasma 1,25-(OH)2-vit D3 levels in patients with detectable levels and treated with renal tubule assist device (RAD) for >20 hours. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

4 Figure 3 Plasma cytokine levels in renal tubule assist device (RAD)-treated patients. Each data point is an individual's baseline pre-RAD treatment level factored by the upper limit of normal for each cytokine. Upper limit of normal levels for G-CSF = 39 pg/mL, IL-6 = 12.5 pg/mL, IL-10 = 7.8 pg/mL, TNF-α= 15.6 pg/mL, and IL-8 = 31.2 pg/mL. The ratios are plotted on a log scale due to the wide spectrum of values. G-CSF, granulocyte-colony stimulating factor; IL, interleukin; TNF-α, tumor necrosis factor-α. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

5 Figure 4 Plasma cytokine levels and ratios for excessively proinflamed patients before and after renal tubule assist device (RAD) therapy. In (A), dashed lines refer to the left axis, and solid lines refer to the right axis. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

6 Figure 5 Acute physiologic scores (APS) for each individual patient while the patient was in the intensive care unit. Patients discharged from the unit prior to day 7 do not have day 7 scores. Patient 026 had only a screening value since life support was discontinued 12 hours post-renal tubule assist device (RAD) therapy. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions


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