1. The Secrets of its Strength
Bone:
The Secrets of its Strength
Bone is Not Just Minerals
It is a Mixture of
Proteins and Minerals P a t h o p y s i l g
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OSTEOPOROSIS

2. Take a wall as an exampleh o p y s i l g
You need cement to
hold the stones together
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OSTEOPOROSIS

3. The cement for the bone isP a t h o p y s i l g
The cement for the bone is
collagen
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OSTEOPOROSIS

4. How the Bone Remains StrongP a t h o p y s i l g
How the Bone
Remains Strong
Replacement of old bone with new one is the way nature preserves the strength of the bone
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OSTEOPOROSIS

5. Bone remodeling The Skeleton is ... Under Construction …from Birth ...P a t h o p y s i l g
The Skeleton is
... Under Construction
…from Birth ...
Until Death
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OSTEOPOROSIS

6. Bone remodeling First … the Osteoclast digs holes into the bone P a ty s i l g
First …
the Osteoclast digs
holes into the bone
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OSTEOPOROSIS

7. the Osteoblast follows ….
…and then… P a t h o p y s i l g
the Osteoblast follows ….
….to replace it
with new bone
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OSTEOPOROSIS

8. Bone remodeling Osteoclast (resorbs bone) Replacement
of old bone with
new one is the
way nature
preserves the
strength of the
bone
Osteoblast (builds bone)
New bone
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OSTEOPOROSIS

9. Osteoporosis … too many Osteoclasts
Pathophysiology
Osteoporosis
Osteoclast
Osteoclast
Osteoclast
Osteoclast
… too many Osteoclasts
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OSTEOPOROSIS

10. Osteoblast Osteoprotegerin (OPG) OPG, a soluble "decoy" receptorh o p y s i l g
inhibits the recruitment,
proliferation and activation
of osteoclasts
by binding to and neutralizing the OPG-L
OPG ligand
(OPG-L)
Osteoblast
(the bone forming cell)
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OSTEOPOROSIS

11. (the bone forming cell)
OPG ligand
(OPG-L)
Osteoprotegerin
(OPG)
Osteoporosis
… too many
OPG-Ligands P a t h o p y s i l g
Osteoblast
(the bone forming cell)
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OSTEOPOROSIS