1. Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease- Oriented Group 
Ronald S. Go, MD, Jeffrey L. Winters, MD, Nelson Leung, MD, David L. Murray, MD, PhD, Maria A. Willrich, PhD, Roshini S. Abraham, PhD, Hatem Amer, MD, William J. Hogan, MBBCh, Ariela L. Marshall, MD, Sanjeev Sethi, MD, PhD, Cheryl L. Tran, MD, Dong Chen, MD, PhD, Rajiv K. Pruthi, MBBS, Aneel A. Ashrani, MD, MS, Fernando C. Fervenza, MD, PhD, Carl H. Cramer, MD, Vilmarie Rodriguez, MD, Alexandra P. Wolanskyj, MD, Stephan D. Thomé, MD, C. Christopher Hook, MD Ronald S. Go, MD, Jeffrey L. Winters, MD, Nelson Leung, MD, David L. Murray, MD, PhD, Maria A. Willrich, PhD, Roshini S. Abraham, PhD, Hatem Amer, MD, William J. Hogan, MBBCh, Ariela L. Marshall, MD, Sanjeev Sethi, MD, PhD, Cheryl L. Tran, MD, Dong Chen, MD, PhD, Rajiv K. Pruthi, MBBS, Aneel A. Ashrani, MD, MS, Fernando C. Fervenza, MD, PhD, Carl H. Cramer, MD, C. Christopher Hook, MD, Vesna D. Garovic, MD, Jennifer C. Yui, MD, Juliana Perez Botero, MD Ronald S. Go, MD, Jeffrey L. Winters, MD, Nelson Leung, MD, David L. Murray, MD, PhD, Maria A. Willrich, PhD, Roshini S. Abraham, PhD, Hatem Amer, MD, William J. Hogan, MBBCh, Ariela L. Marshall, MD, Sanjeev Sethi, MD, PhD, Cheryl L. Tran, MD, Dong Chen, MD, PhD, Rajiv K. Pruthi, MBBS, Aneel A. Ashrani, MD, MS, Fernando C. Fervenza, MD, PhD, Carl H. Cramer, MD, Vilmarie Rodriguez, MD, Alexandra P. Wolanskyj, MD, Stephan D. Thomé, MD, C. Christopher Hook, MD Ronald S. Go, MD, Jeffrey L. Winters, MD, Nelson Leung, MD, David L. Murray, MD, PhD, Maria A. Willrich, PhD, Roshini S. Abraham, PhD, Hatem Amer, MD, William J. Hogan, MBBCh, Ariela L. Marshall, MD, Sanjeev Sethi, MD, PhD, Cheryl L. Tran, MD, Dong Chen, MD, PhD, Rajiv K. Pruthi, MBBS, Aneel A. Ashrani, MD, MS, Fernando C. Fervenza, MD, PhD, Carl H. Cramer, MD, C. Christopher Hook, MD, Vesna D. Garovic, MD, Jennifer C. Yui, MD, Juliana Perez Botero, MD 
Mayo Clinic Proceedings 
Volume 91, Issue 9, Pages (September 2016)
DOI: /j.mayocp
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2. Figure 1 Clinicopathologic overview of thrombotic microangiopathy.
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3. Figure 2
Clinical suspicion of thrombotic microangiopathy. ADAMTS13 = a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13; APLS = antiphospholipid syndrome; DGKE = diacylglycerol kinase-ε; DIC = disseminated intravascular coagulation; HIV = human immunodeficiency virus; HTN = hypertension; PLG = plasminogen; SLE = systemic lupus erythematosus; THBD = thrombomodulin; TTP = thrombotic thrombocytopenic purpura.
Associated drugs data from Blood.9
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4. Figure 3
Care pathway 1: general considerations and Shiga toxin–induced TMA. CFH = complement factor H; CP = care pathway; DGKE = diacylglycerol kinase-ε; TMA = thrombotic microangiopathy; TPE = total plasma exchange; TTP = thrombotic thrombocytopenic purpura.
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5. Figure 4
Care pathway 2: TTP. Hgb = hemoglobin; LDH = lactate dehydrogenase; Plt = platelet count; TPE = therapeutic plasma exchange; TTP = thrombotic thrombocytopenic purpura.
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6. Figure 5
Care pathway 3: hyperhomocysteinemia. CP = care pathway; ULN = upper limit of normal.
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7. Figure 6
Care pathway 4: precipitating factors. CP = care pathway; DIC = disseminated intravascular coagulation.
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8. Figure 7
Care pathway 5: probable complement dysregulation. CFH = complement factor H; CP = care pathway; TPE = therapeutic plasma exchange.
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9. Figure 8
Care pathway 6: renal transplantation. CP = care pathway; TPE = therapeutic plasma exchange.
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10. Figure 9 Care pathway 7: stem-cell transplantation. CP = care pathway.
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11. Figure 10
Care pathway 8: complement mutations. CFB = complement factor B; CFH = complement factor H; CFI = complement factor I; THBD = thrombomodulin; TPE = therapeutic plasma exchange.
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12. Figure 11
Care pathway 9: coagulation protein mutations. DGKE = diacylglycerol kinase-ε; PLG = plasminogen; TPE = therapeutic plasma exchange.
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