Presentation is loading. Please wait.

Presentation is loading. Please wait.

Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences  Serge Erlinger, Irwin M. Arias, Daniel.

Similar presentations


Presentation on theme: "Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences  Serge Erlinger, Irwin M. Arias, Daniel."— Presentation transcript:

1 Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences  Serge Erlinger, Irwin M. Arias, Daniel Dhumeaux  Gastroenterology  Volume 146, Issue 7, Pages (June 2014) DOI: /j.gastro Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 Schematic representation of the UGT1A1 locus and UGT1A1 protein. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

3 Figure 2 Schematic view of bilirubin transport by the hepatocyte. (Inset) Localization of UGT1A1 in the reticulum endoplasmic membrane and transport of uridine diphospho-glucuronic acid (UDPGA), bilirubin, and bilirubin glucuronide across the endoplasmic reticulum membrane. UCB, unconjugated bilirubin; Alb, albumin; BG, bilirubin glucuronide. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

4 Figure 3 Schematic view of the transporters involved in inherited disorders of bilirubin metabolism. UCB, unconjugated bilirubin; Alb, albumin; BG, bilirubin glucuronide. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions


Download ppt "Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences  Serge Erlinger, Irwin M. Arias, Daniel."

Similar presentations


Ads by Google