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Magnesium Foams to Regrow Bones
By Justin Womack
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Bone Damage Possess the ability to self heal
This ability cannot work on injuries that reach the critical size defect Can be caused by: Congential Defects Cancer Resections Extreme Trauma Critical Size defect estimated at 2.5 cm in length Defect greater than 2.5 x bone diameter
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Bone Tissue Engineering
The goal of bone tissue engineering is to repair, regrow, and restore function to bone tissues damaged beyond the natural healing capacity of the human body without the use of another bone source. Three main elements needs for Tissue Engineering: Properly differentiated stem cells A biocompatible scaffold Stimulating Factors
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The Scaffold A bone scaffold must: Provide mechanical support
Provide template for cell attachment Be Osteoinductive, Osteoconducive, and allow for Osseointegration Degrade at a similar rate of new tissue formation Calcium phosphate scaffold Osteoinduction is the recruitment of immature cells and the stimulation of these cells to develop Osteoconduvice means that bone grows on a surface. Osseointegration is the stable anchorage of an implant achieved by direct bonet to implant contact.
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The Full Process
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3D Printing Typical 3d printing scaffold design. My lab, however, must take a different route.
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Methods
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Results
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Conclusion Magnesium Foams prove to be a promising option for the future of bone tissue engineering. This process shows promising producing porous structures for tissue engineering, however, the process needs modification of the molding substance in order to make designs at a better rate and with better precision.
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