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Cholera By: Juan Camacho
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Vibrio cholera is a comma-shaped bacterium that lives in brackish or salt water
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The primary symptoms of cholera are profuse diarrhea and vomiting of clear liquid
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Cholera is transmitted via the fecal-oral route by contaminated water or food.
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John Snow identified the mode of transmission during an epidemic in London in 1854
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In late 2010, after the earthquake, Cholera reappeared in Haiti, for the first time in more than 100 years
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V. cholerae propels itself to the lining of your intestinal wall.
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The toxin that causes cholera’s symptoms is actually encoded in a bacteriophage
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Cholera toxin activates cAMP affecting chloride ion and water homeostasis
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Preventing Cholera is relatively simple, involving providing clean water, handling sewage and education on hygiene
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Two oral vaccines are available but are not currently used in the US
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Cholera can be effectively treated by replacing fluids lost as fast as they are being lost.
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Ali, M. , Nelson, A. R. , Lopez, A. L. , & Sack, D. A. (2015)
Ali, M., Nelson, A. R., Lopez, A. L., & Sack, D. A. (2015). Updated Global Burden of Cholera in Endemic Countries. PLoS Negl Trop Dis PLOS Neglected Tropical Diseases, 9(6). Lencer, W. (2003). The intracellular voyage of cholera toxin: Going retro. Trends in Biochemical Sciences, 28(12), Lucas, M. E., Deen, J. L., Seidlein, L. V., Wang, X., Ampuero, J., Puri, M., Clemens, J. D. (2005). Effectiveness of Mass Oral Cholera Vaccination in Beira, Mozambique. New England Journal of Medicine N Engl J Med, 352(8), Lutz, C., Erken, M., Noorian, P., Sun, S., & Mcdougald, D. (2013). Environmental reservoirs and mechanisms of persistence of Vibrio cholerae. Front. Microbiol. Frontiers in Microbiology, 4. Mcleod, S. M., Kimsey, H. H., Davis, B. M., & Waldor, M. K. (2005). CTXφ and Vibrio cholerae : Exploring a newly recognized type of phage-host cell relationship.Molecular Microbiology, 57(2),
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