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Published byἩρωδιάς Κουταλιανός Modified over 6 years ago
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FSH receptor gene variants are rarely associated with premature ovarian failure
Kathryn J. Woad, Deborah Prendergast, Ingrid M. Winship, Andrew N. Shelling Reproductive BioMedicine Online Volume 26, Issue 4, Pages (April 2013) DOI: /j.rbmo Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions
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Supplementary Figure 1 DNA sequencing electropherograms illustrating the novel heterozygous substitution c.1411A>T (boxed) observed in one POF patient, following sequencing in the forward (a) and reverse (b) directions (and then reverse complementation; (b) PCR reactions were cloned into a plasmid to separate the alleles and then sequenced; 1411A (c) and 1411T (d). Multiple sequence alignment (e) of homologous regions of human thyroid stimulating hormone receptor (TSHR), luteinising hormone receptor (LHR) and follicle stimulating hormone receptor (FSHR) protein sequences and (f) of FSHR protein sequences across multiple species to show conservation of isoleucine 471 (boxed). Reproductive BioMedicine Online , DOI: ( /j.rbmo ) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions
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