1. The Current Status of Neoadjuvant Therapy in HER2-Positive Breast Cancer

3. Program Goals

4. Neoadjuvant Chemotherapy: Historical Context

5. pCR

6. Goals of Modern Neoadjuvant Therapy

7. Eligibility for Neoadjuvant Approach

8. Case 1

9. Case 1 (cont)

10. NeoSphere Trial 2015 Update

11. Other Pertuzumab + Trastuzumab Trials

12. Dual Blockade of HER2 With Lapatinib + Trastuzumab

13. Adverse Effects of Neoadjuvant Regimens for HER2-Positive Breast Cancer

14. Case 1 (After Neoadjuvant Regimen)

15. Case 2: Alternatives to Dual HER2 Blockade and Chemotherapy

16. MARIANNE Update: 2015

17. Summary: Neoadjuvant HER2-Directed Therapy

18. Abbreviations

19. Abbreviations (cont)

20. References

21. References (cont)

22. References (cont)

23. References (cont)

24. References (cont)