1. Absent Response of Intracranial Melanoma Metastases Harboring BRAF V600E Sequence Variation to Vemurafenib 
Donato D'Alonzo, MD, Katharina Glatz, MD 
Mayo Clinic Proceedings 
Volume 88, Issue 12, Pages e151-e152 (December 2013)
DOI: /j.mayocp
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2. Figure 1
Macroscopic findings. Note innumerable pigmented melanoma metastases in the ileum (A) and brain (B).
Mayo Clinic Proceedings  , e151-e152DOI: ( /j.mayocp )
Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

3. Figure 2
Microscopic findings. A, Ileal metastasis consisting predominantly of pigment-laden macrophages and scattered viable tumor cells (hematoxylin-eosin, original magnification ×200). B, Viable brain metastasis in the frontal cortex with single interspersed melanophages (hematoxylin-eosin, original magnification ×200). C, On immunohistochemical analysis, tumor cells of the brain metastasis stained positive for the BRAF V600E sequence variation–specific antibody. Note strong staining of melanophages, BRAF V600E, VE1, (ultrared, original magnification ×200).
Mayo Clinic Proceedings  , e151-e152DOI: ( /j.mayocp )
Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions