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Enzyme Mechanisms
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RNaseA Acid-Base Catalysis
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2. Amino Acid Decarboxylase Covalent Catalysis
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3. Enolase Metal Ion Catalysis
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4. Lysozyme
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“Phillips Mechanism”
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5. Serine Proteases acid/base + covalent catalysis
Examples: chymotrypsin trypsin subtilisin thrombin
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http://bmbiris. bmb. uga
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Catalytic triad
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Peptide bond cleavage !
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6. Aspartate Proteases Examples: Pepsin HIV protease
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HIV protease
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