1. Accelerated NaCl-induced hypertension in taurine-deficient rat: Role of renal function 
M.S. Mozaffari, C. Patel, R. Abdelsayed, S.W. Schaffer 
Kidney International 
Volume 70, Issue 2, Pages (July 2006)
DOI: /sj.ki
Copyright © 2006 International Society of Nephrology Terms and Conditions

2. Figure 1
The flow diagram summarizes experimental protocols I–IV. Number of animals in each group is indicated in parenthesis. UNX: uninephrectomized.
Kidney International  , DOI: ( /sj.ki )
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3. Figure 2
Urine samples (48-h; protocol I) were collected from taurine-deficient and control animals for assessment of (a) cumulative fluid intake, (b) cumulative urine excretion, (c) ratio of urine output to fluid intake, and (d) urine osmolality. Data are means±s.e.m. of 4 rats/group. *P<0.05 compared to the control group.
Kidney International  , DOI: ( /sj.ki )
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4. Figure 3
β-Alanine treatment caused a significant reduction in tissue taurine content of the kidney and the heart. The right kidney was removed from the animals that were fed the basal or normal NaCl diet. The left kidney and the heart were removed at the conclusion of the experiment and thus were exposed to 6 weeks of high NaCl diet and hypertension (i.e., protocol II). Data are means±s.e.m. of four control and five taurine-deficient rats. *P<0.05 compared to the control group. #P<0.05 compared to the right kidney.
Kidney International  , DOI: ( /sj.ki )
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5. Figure 4
Line graphs showing the effect of uninephrectomy alone and in combination with dietary NaCl excess on (a) daily fluid intake, (b) sodium excretion, (c) urine excretion, (d) potassium excretion, (e) urine osmolality, and (f) protein excretion in taurine-deficient and control rats. Data are means±s.e.m. of four control and five taurine-deficient rats. *P<0.05 compared to the other group at the same time.
Kidney International  , DOI: ( /sj.ki )
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6. Figure 5
The taurine-deficient rats developed a more exaggerated increase in mean arterial pressure, systolic pressure, and diastolic pressure than their control counterparts. Data are means±s.e.m. of four control and five taurine-deficient rats. *P<0.05 compared to the control group.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2006 International Society of Nephrology Terms and Conditions

7. Figure 6
Bar graphs showing changes in (a) mean arterial pressure (MAP) and (b) heart rate of hypertensive control and hypertensive taurine-deficient (TD) rats in response to the intravenous administration of either phenylephrine or sodium nitroprusside. Data are means±s.e.m. of four control and five taurine-deficient rats.
Kidney International  , DOI: ( /sj.ki )
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8. Figure 7
Line graphs showing the (a) diuretic, (b) natriuretic, and (c) kaluretic responses of UNX control and taurine-deficient rats to a 5% isotonic saline volume load; changes in (d) glomerular filtration rate and (e) fractional excretion of fluid and (f) sodium are also shown. These responses were determined 3 weeks post-uninephrectomy while the animals were fed the basal NaCl diet (protocol III). Data are means±s.e.m. of 7 rats/group. *P<0.05 compared to the taurine-deficient group at the same time point.
Kidney International  , DOI: ( /sj.ki )
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9. Figure 8
(a and b) Mean arterial pressure and heart rate of the (○ or ▵; n=6) UNX control and (• or ▴; n=6) taurine-deficient rats following consumption of a high NaCl diet. The hemodynamic values obtained from the restrained animal via the tail-cuff technique are designated by circles, whereas corresponding intra-arterial values obtained from the freely moving animal are depicted by triangles. Also shown are the hemodynamic data during two-kidney stage when the animals were fed a normal NaCl diet (□ or ▪). (c) Daily protein excretion 12 weeks after initiation of dietary NaCl excess. (d) Molecular weight distribution of urinary proteins for three hypertensive (lanes 3–5) and three hypertensive taurine-deficient (lanes 6–8) rats; samples from two age- and strain-matched normotensive rats (lanes 9–10) and bovine serum albumin (lane 2) are included for comparison. *P<0.05 compared to the other group.
Kidney International  , DOI: ( /sj.ki )
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10. Figure 9
Line graphs showing (a) diuretic and (b) natriuretic responses of the hypertensive control and taurine-deficient (TD) rats to either a (○ or •) 5% saline volume expansion (SVE) or administration of (▵ or ▴) atrial natriuretic peptide (ANP; 0.5 μg/min/kg, intravenously). Data are means±s.e.m. of 6 rats/group/condition.
Kidney International  , DOI: ( /sj.ki )
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11. Figure 10
Hematoxylin–eosin sections of the kidneys from (a) hypertensive control and (b–c) hypertensive taurine-deficient rats. (b–d) Presence of mononuclear cell infiltrates in the hypertensive taurine-deficient kidney, which display intense immunoreactivity to (d) histiocyte marker CD68; (d, inset) the hypertensive kidney shows no positive staining in response to CD68. The magnification is indicated on each panel and arrow (b) shows round cell infiltrates. Original magnification (a, b, d) × 200; (c) × 40; and (d, inset) × 100.
Kidney International  , DOI: ( /sj.ki )
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