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Association of celiac disease and intestinal lymphomas and other cancers
Carlo Catassi, Italo Bearzi, Geoffrey K.T. Holmes Gastroenterology Volume 128, Issue 4, Pages S79-S86 (April 2005) DOI: /j.gastro Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 1 Appearance of the small intestinal mucosa in a case of EATL. The tumor consists of small to medium size T cells (H&E staining, original magnification 40×; insert: H&E staining, original magnification 400×). The T-cell lymphoma is associated with a typical celiac enteropathy (severe flattening of the villi with crypt hypertrophy). Gastroenterology , S79-S86DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 2 Histologic findings in EATL. (A) Infiltrate of predominantly small and medium size lymphoid cells with mixture of large blastic cells, in part multinucleated (arrows) (H&E staining, original magnification 200×). (B) On immunohistochemistry, both small and large multinucleated cells are positive for UCLH1 (arrow), a marker of T cells (original magnification 200×). Gastroenterology , S79-S86DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 3 Gross appearance of EATL. An ulcerated mass causing stenosis of the lumen is evident in the small intestine. Gastroenterology , S79-S86DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 4 In the past (A), the prevalence of lymphoma in patients with CD was overestimated because the frequency of this complication was compared with the number of clinically diagnosed patients with CD (the tip of the celiac iceberg). More realistic estimates have been given by recent studies counting also (B) undiagnosed CD cases in both the NHL and the control groups. Gastroenterology , S79-S86DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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