1. Hormonal Control of Reproductive Tract Function

2. The Menstrual Cycle

3. Menstrual Cycle Events
High FSH – Follicular growth, E2 secretion from granulosa
Moderate E2 – Positive FSH feedback
High E2 – Negative FSH feedback, endometrial proliferation, stimulation of LH surge
LH surge – ovulation, CL formation
CL – secretion E2 and P4, inhibits FSH, LH
No fertilization – CL degenerates, E2 and P4 drop, menstrual flow commences
Low E2 – cycle begins anew

4. Hormonal Manipulation of Repro Tract Function
GnRh agonists/antagonists
P4/E2 pills
RU486 (anti – P4)

5. Hormonal Control of Male Reproductive Function
LH – Influences Leydig cell T production and is influenced by T levels; ABP from Sertoli cells concentrates T levels to support meiosis
FSH – Controlled by levels of T, but also by inhibin production from Sertoli cells
Testosterone supports spermatogenesis, FSH required for spermiogenesis
LH – Assists in release of sperm from testis