1. Hepatitis virus Herpes virus
Virus DNA
Hepatitis virus
Herpes virus

3. Characteristic Hepatitis Virus

4. Hepatitis virus Produce acute inflammation of the liver
In Chronic active hepatitis :
Histologic change from inflammation and necrosis to collaps of the normal reticulum framework with bridging between the portal triads or terminal hepatic vein
Resulting in a clinical illness
Fever
Gastrointestinal symptoms: nausea, vomite
Jaundice

5. Hepatitis B

6. Replication of hepatitis B virus

7. Virus Hep-B HBV establishes chronic infection
Major factor in the evantual development of liver disease and hepatocelluler carcinoma
Transmission modes and response to infection is vary
Depending on the age at time of infection
Infant: during infancy,from infected household contact  chronic
High-risk group

8. High-risk group infected by HBV
Parenteral drug abusers
Health care personnel
Multiply trasfused patients
Organ transplant patients
Hemodialysis patient and staff
Newborn infant to mother with Hep-B
etc

9. HBV HBsAg can be detect: How HBV transmit to other person?
Saliva, nasopharyngeal washing, semen, mestrual fluid, vagina secretion, blood
How HBV transmit to other person?
HBeAg + in carrier person  assumed all the body fluids is infectious
Precaution: vaccination
Laboratory feature:
Interpretation of HBV serologic markers

10. Clinical and serologic event HBV

11. Herpes Viruses Ability : Frequent reactivation: A large virus
establish lifelong persistent infections in their host
To undergo periodic reaction
Frequent reactivation:
in immunosupressed patients cause serious health complications
May be clinically quite different from the primary infection
A large virus

13. Herpes simpleks virus Extremely widespread in human population
Broad host range
Able to replicate in many types of cells
Grow rapidly and highly cytolytic
Common recurrences
Two distinct HSV:
HSV type 1  spread by contact (often saliva)
HSV type 2  transmitted sexually or maternal genital infection to a newborn

14. HSV… HSV-1 : site latency at trigeminal ganglia
HSV-2: site latency at sacral ganglia
How the virus enconter the host?
Mucosal surface or broken skin
the clinical finding for HSV infection
Oropharyangeal infection
Keratokonjunctivitis
Genital herpes
Skin infection
Encepalitis
Neonatal herpes

15. Laboratory finding Stain (giemsa stain) PCR serology
Scraping base of vesicle  multinucleated giant cell
PCR
serology

16. Varisella zozter virus
Highly contagious disease, chiefly of children
Characterized clinically:
Generalized vesicular eruption of the skin and mucous membranes
A rash limited in distribution to the skin innervated by a single sensory ganglion
may be severe in adult and immunocompromised children

17. Pathogenesis varisella:

18. Varisella zozter virus
Acute skin lesion
Also acute inflammation of the sensory nerves and ganglia
Induce vesicle formation
Often only single ganglion may be involved
Distribution skin lesion corresponds closely to the areas of innervation from an individual dorsal root ganglion
It is not clear what trigger reactivation of latent varisella-zozter virus in ganglia

19. Varisella-zozter virus symptom
malaise, fever, rash start from trunk,then face, limb, buccal, paryngeal mucosa
In 5 days: develop hundreds skin lesion
Zozter
Start with severe pain in the area of skin or mucosa
Few days after: vesicle appears over the skin supplied by the affected nerves
Complication: post herpetic neuralgia

20. Laboratory finding Tzanck smear: Rapid diagnostic prosedure:
Scraping or swab based of vesicle
Rapid diagnostic prosedure:
Viral DNA/virus specifis antigen in vesicle fluid, skin scraping, or biopsy material
Cell culture

21. Therapy and prevention
The efectivity of antiviral:
For immunosuppresed patients, halt progression
The prevention: vaccin

22. Cyto Megalo Virus (CMV)
Largest genetic content in herpesvirus
Very spesies-spesific and cell type-specific
Replicate in vitro inhuman fibroblast
Infect intrauterin congenital anomalies
Most CMV infection is in subclinical
Clinical: An infectious mononucleosis-like syndrome  cell enlarged
Severe infection in immunosuppressed

23. patology

24. CMV How virus transmission Laboratory diagnosis?
What are the treatments?