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Published byErick Cummings Modified over 6 years ago
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Hepatic CD141+IFNλ+ DC subset: One against all?
Claudia Wegscheid, Khalil Karimi, Gisa Tiegs Journal of Hepatology Volume 60, Issue 1, Pages 9-11 (January 2014) DOI: /j.jhep Copyright © 2013 European Association for the Study of the Liver Terms and Conditions
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Fig. 1 Possible role of CD141+ DC subsets in the immune response. Upon viral infection CD141+CLEC9A+ DCs become activated and release IFNlambda (IFN-λ). Subsequently, conventional CD8+ T cells are recruited to the liver to clear the infection. On the other hand, ILT3+ILT4+CD141+ DCs become activated with several stimuli and might induce the regulation of the immune response, e.g., by induction of regulatory T cells (Tregs). This might promote the healing and regeneration process in the liver. Journal of Hepatology , 9-11DOI: ( /j.jhep ) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions
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