1. Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.150
Figure 5 Experimental animal models to study hepatitis E virus Orthohepevirus A
Figure 5 | Experimental animal models to study hepatitis E virus Orthohepevirus A. Experimental animal models that have been used to study hepatitis E virus (HEV) include non-human primates, swine, rabbits and human liver chimeric mice. Chimpanzees, rhesus monkeys and cynomolgus monkeys were the earliest animal models in HEV research and have been used to study HEV pathogenesis and vaccine efficacy. Swine, which are naturally infected with genotypes 3 and 4 of HEV and can transmit these strains to humans, have been used to determine the infectivity of genotype 3 isolates and to show extrahepatic replication sites of HEV. Recently, an iatrogenically immunosuppressed swine model was shown to support chronic infection with genotype 3, and similarly, human liver chimeric mice can support chronic infection with genotype 1 and genotype 3 HEV.
Nimgaonkar, I. et al. (2017) Hepatitis E virus: advances and challenges
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