1. Making the Case for Metabolic Surgery in Patients With Obesity and T2DM

3. Introduction/Overview

4. Obesity and T2DM: Key Correlations

5. Improvements in Metabolic Parameters Pre- and Post-Roux-en-Y Surgery

6. Post-Hoc Analysis Look AHEAD: The Importance of ≥ 10% Weight Loss

7. Weight Loss Is Difficult, Weight Loss Maintenance Even More So

8. Overall Strategy for the Treatment of Obesity[a,b]*

9. Obesity: Imbalance of Energy Regulation

10. SCALE: Change in Body Weight (%), Liraglutide vs Placebo

11. Roux-en-Y Gastric Bypass Induces System-Wide Physiological Changes[a,b]

12. Mechanisms of Bariatric Surgery[a-c]

13. Factors Associated With Long-Term Weight Loss Maintenance

14. "The Biggest Loser" and the Persistence of Metabolic Adaptation

15. Early Treatment Response and Stopping Rules

16. Characteristics of More and Less Successful Weight Loss Losers After Bariatric Surgery

17. Bariatric (Metabolic) Surgery Modalities

18. Bariatric Surgery Modalities: BPD

19. Diabetes Surgery Summit-II Recommendations

20. Despite Advances in Treatment, a Significant Proportion of Patients With T2DM Have Not Reached Target HbA1c Levels

21. Bariatric Surgery vs Intensive Medical Therapy for T2DM: STAMPEDE Trial

22. Clinical Trial Results of HbA1c Levels After Roux-en-Y Surgery vs Medical Treatment

23. Impact of Bariatric Surgery on Life Expectancy in Persons With T2DM and Severe Obesity

24. Surgery Leads to Lower Costs and Greater Health Gains vs Optimal Medical Management

25. Prevention of T2DM With Bariatric Surgery vs Control: SOS Study

26. AACE/TOS/ASMBS Guidelines: Criteria for Bariatric Surgery Recommendation

27. Meta-Analysis of Bariatric Surgery Risk

28. Anemia and Nutritional Deficiencies Associated With Bariatric Surgery

29. Summary and Conclusions

30. Abbreviations

31. Abbreviations (cont)