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Published byAnnice Melton Modified over 6 years ago
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Giant Cell Arteritis: Timely Diagnosis and Emerging Treatment Strategies
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Overview of GCA
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Overview of GCA (cont)
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Epidemiologic Factors Related to GCA
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Headache
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Visual Signs and Symptoms
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Optic Disc in GCA
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Vision Loss in GCA
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Jaw Claudication
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The PMR Connection
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Diagnosing GCA
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Normal TA, 4X, H&E Stain
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Normal TA, 4X, Elastin Stain
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TA, 4X, H&E Stain: Evidence of Arteritis
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TA, 4X, Elastin Stain: Evidence of Arteritis
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Ultrasound: Normal TA, Right Parietal Ramus
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Ultrasound: Normal Right Parietal Ramus
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Ultrasound: Hypoechoic Circumferential Wall Thickening Due to Vasculitic Wall Edema -- Halo Sign
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Ultrasound: Left Mid-Subclavian Artery With Hypoechoic Wall Edema and Halo Sign
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Fused PET CT: Increased FDG Uptake in Ascending and Descending Aorta Walls
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Diagnostic Algorithm for GCA
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Conventional Treatments
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Steroids: Not Effective in Long-Term Disease Control (GiACTA)
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Methotrexate in GCA
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Infliximab in GCA
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New Knowledge on Pathophysiology of GCA
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Emerging Treatments: TCZ
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Relapse-Free Survival After Stopping TCZ
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GiACTA Trial
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Sustained Remission Primary and Key Secondary Endpoints
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Sensitivity Analysis
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Time to First Flare Following Clinical Remission
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Steroid Dosing, Without TCZ
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TCZ Had Significant Steroid-Sparing Effect
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Safety Overview
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IL-12/23 Inhibitor: Ustekinumab
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IL-23 Inhibitor: Ustekinumab (cont)
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Ustekinumab: Conclusions
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Concluding Remarks
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Abbreviations
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Abbreviations (cont)
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