1. The Role of Anticholinergic Therapy in Moderate to Severe Asthma

3. Introduction

4. Definitions of Severe and Uncontrolled Asthma

5. Asthma in The World

6. Uncontrolled Severe Asthma Is a Significant Problem

7. Guideline Goals for Successful Asthma Management

8. GOAL: 22-38% of Asthma Patients Remained Uncontrolled Despite Optimal ICS/LABA-Treatment

9. Uncontrolled Asthma Checklist

10. What Are the Possible Reasons for Poor Disease Control?

11. Asthma Control in the INSPIRE Study

12. Asthma in Children 5 Years and Younger

13. Asthma Treatment in Adults and Adolescents

14. Stepwise Approach to Long-Term Management of Asthma in Children 5 Years and Younger

15. Asthma Treatment in Adults and Adolescents

16. The Cholinergic System Contributes to Bronchoconstriction in Asthma

17. The TALC Study Trial Design

18. Primary and Secondary Outcomes

19. Tiotropium in Asthma Poorly Controlled With ICS/LABA

20. Tiotropium in Asthma Poorly Controlled With ICS/LABA (cont)

21. Tiotropium or Salmeterol as Add-On Therapy to ICS for Moderate Symptomatic Asthma

22. Tiotropium or Salmeterol as Add-On Therapy to ICS for Moderate Symptomatic Asthma (cont)

23. Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose ICS

24. Tiotropium in Asthma <18 Years

25. Tiotropium in Asthma <18 Years (cont)

26. Tiotropium Efficacy

27. Tiotropium in Asthma

28. Tiotropium Safety (Moderate Asthma)

29. Tiotropium Safety (Severe)

30. Safety of Add-On LAMA Therapy

31. Treatment Options in Step 5

32. Uncontrolled Asthma Checklist

33. Conclusion

34. Abbreviations

35. Abbreviations (cont)