1. Statistical & Quantitative Genetics of Disease
2017 SISG Module 18:
Statistical & Quantitative Genetics of Disease
Converging fields of genetics, epidemiology & genetic epidemiology -same concepts different language
Naomi Wray
Psychiatric genetics
John Witte
Cancer genetics

2. Course Outline Naomi lecture practical Coffee John lecture
Wednesday afternoon
Lecture 1: Single locus disease model; Power calculation for disease model (Naomi)
Lecture 2: Single locus disease analysis (John)
Thursday morning
Lecture 3: Genetic epidemiology of disease; Heritability of liability (Naomi)
Lecture 4: Summary statistics: LD score & Variance explained (John)
Thursday afternoon
Lecture 5: Multi-locus disease model (Naomi)
Lecture 6: Hierarchical modeling & interactions: gene-environment, epistasis (John)
Friday Morning
Lecture 7: Pleiotropy (John)
Lecture 8: Rare variants and individual-level prediction (John)
Friday afternoon
Lecture 9: Risk Prediction (Naomi)
Lecture 10: SNP-h2,rg (Naomi)
Naomi lecture
practical
Coffee
John lecture
More quantitative genetics theory
More statistics/data analysis

3. Course dropbox All materials can be found here
9iaf/AAB8ilCWNtE-h6GQ4iUA-ix5a?dl=0
We will use the dropbox to update materials (eg answer sheets, during the course)