1. *Lipoma: -well-circumscribed -homogenous -fatty cut surface -soft
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2. Bland-looking nuclei…small and at the periphery
Mature fatty tissue
Bland-looking nuclei…small and at the periphery
Large one fat vacuole
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3. Heterogenous cut surface Fixed to the skin and may ulcerate
Large
Firm to hard
Fleshy
Heterogenous cut surface
Fixed to the skin and may ulcerate
Malignant soft tissue tumor
…this example is liposarcoma
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4. This cell is characteristic and it is called: lipoblast
liposarcoma
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5. Intradermal nevus (the most common type of nevus)
Epithelioid benign cells
maturation
In melanoma: in addition to
atypia and invasion, the
maturation is lost
Lymphocyte-like benign cells
Spindle benign cells
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6. The cytoplasm of the cell is filled with this dark brown pigment
Pigmented nevus
The cytoplasm of the cell is filled with this dark brown pigment
(melanin)
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7. …each cell within lacuna has 1 nucleus
Normal cartilage
…small nuclei
…each cell within lacuna
has 1 nucleus
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8. Chondrosarcoma …notice the atypia
…some cells have more than 1 nucleus in each cytoplasm (binucleation and multinucleation)
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9. Malignant glands with severe architectural
disturbance
Lung tissue
Adenocarcinoma
…May be metastatic or primary
…do immunostaining
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10. Stromal reaction (fibrosis) around cancer…= desmoplasia
Metastatic adenocarcinoma in lymph node
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11. Metastatic squamous cell carcinoma in lymph node
Keratin pearl

12. Like previous image

13. Melanoma …irregular borders …heterogenous with different colors
…underlying tissue destruction
…large size
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14. moderate grade squamous dysplasia (changes in lower two thirds)
Most common site of these changes is in transition zone (junction between ecto- and endocervix)
Severe squamous dysplasia (full-thickness changes)… = squamous cell carcinoma in situ
moderate grade squamous dysplasia (changes in lower two thirds)
Low grade squamous dysplasia (changes only in lower third)
Robbins and Cotran pathologic basis of disease 9th edition
CIN = cervical intraepithelial neoplasia
The main cause is HPV
Can be detected by cervical (Pap) smear before squamous cell carcinoma occurs
Ectocervix: stratified squamous non-keratinized

15. THANK YOU