1. History of Genetics
Mendel’s Work

2. What is Genetics? The science of Heredity
The way by which traits are passed from parent to offspring, or “inherited”

3. Who was Mendel?
Gregor Mendel was an Austrian monk who was the first to understand certain patterns of inheritance
He did so by crossing different types of pea plants in carefully planned experiments

4. Why pea plants?
1.) They have many different characteristics that have two distinct forms

5. Why pea plants?
1.) They have many different characteristics that have two distinct forms
2.) They are self-pollinating (can fertilize themselves) because each flower has both male and female parts

6. Why pea plants?
1.) They have many different characteristics that have two distinct forms
2.) They are self-pollinating (can fertilize themselves) because each flower has both male and female parts
3.) They are “low maintenance” plants
Easy to care for
Rapid life cycle

7. Mendel’s Experiment
Mendel performed crosses only looking at one trait: MONOHYBRID CROSS
Step 1: Mendel allowed plants that had each type of trait to self-pollinate for several generations (to ensure the production true-breeds). P generation
Step 2: Mendel crossed two P generation plants that had “opposite” traits. Produced F1 generation
Step 3: Mendel allowed F1 generation to self-pollinate. Produced F2 generation

8. Mendel’s Experiment
After each pollination, Mendel recorded the number of plants that had each trait

9. Results to Note:
When Mendel crossed true breed purple flowers with true breed white flowers, all of the offspring in the F1 generation had purple flowers.
After the F1 generation was left to self-pollinate, the F2 generation resulted in 705 purple flowered plants and 224 white flowered plants
Ratio= 705:224 OR 3:1
This 3:1 ratio was seen in all seven of the traits.

10. Hypotheses Based on Mendel’s Results:
1.) For each inherited trait, an individual has two copies of the gene – one from each parent.
2.) There are alternative versions of genes called alleles.
3.) When two different alleles are present together, one of them might be completely expressed, while the other may have no effect on the physical appearance.
Expressed trait = dominant (capital letter)
Trait not expressed when dominant is present = recessive (lower case letter)

11. What did Mendel Think of All This?
Mendel correctly concluded that each pea has two separate “heritable factors” for each trait – one from each parent

12. Homozygous vs. Heterozygous
If the two alleles of a particular gene present in an individual are the same, the individual is said to be homozygous
If the alleles of a particular gene present in an individual are different, the individual is said to be heterozygous

13. Working with Mendel’s Rules of Genetics:
All of Mendel’s work was based upon a mathematical field that deals with how likely something is to happen, called probability
We now use devices called Punnett squares to calculate these probabilities

14. Working with Mendel’s Rules of Genetics:
How to set up a monohybrid Punnett square:
Draw a square and divide it into 4 squares.
Collect Parental information (Tt x tt)
Place one letter from first parent beside each row; place one letter from second parent above each column:
Multiply to fill each sq. t t T T t t

15. Working with Mendel’s Rules of Genetics:
Calculate a genotypic ratio: Genotype is genetic make-up
In this case, each offspring has a 50% chance of having the genotype Tt and a 50% chance of having the genotype tt
Calculate a phenotypic ratio: Phenotype is the physical representation of the gene
In this case, each offspring has a 50% chance of being able to roll their tongue and a 50% chance of not being able to t t T T T t t t t t t t