1. GROUPS and TOPICS TKRKPO Dysfunction Junction
Glioblastoma
Alternating Hemiplegia
Cysticercosis
Dysfunction Junction
Schizophrenia
PTSD
TBD
Narcolepsy
Sydenham Chorea
The Traumatic Fingerprint Traumatic Brain Injury
Brain Budz
Angelman Syndrome
Obsessive-Compulsive Disorder
The Chain Ganglion
CBD treatment in epilepsy
siRNA/shRNA treatment in Huntington’s
Sand Sharks
Brain Aneurysm
Smooth ER
Cri-Du-Chat
anti-NMDA receptor encephalitis .

2. Huntington’s Early onset neurodegenerative disorder
Affects ~3-7 per 1000,000
Autosomal dominant mutation in Htt gene expanding the CAG repeats from normal to
Movement, cognitive and psychiatric disorders with a wide spectrum of signs and symptoms
15 to 20 Years following diagnoses
Affects the whole brain but primarily the basal ganglia
No cure only treatments for symptoms

4. Team Workshop 1: Draw the general location of the basal ganglia
Team Workshop 1: Draw the general location of the basal ganglia? Hypothesize why damage to this area occurs early in Huntington’s? How could you test your hypothesis?

5. Team Workshop 2: Use STRING to investigate Htt
Team Workshop 2: Use STRING to investigate Htt? Are there any proteins involved in oxidative stress/cell death?

6. Team Workshop 3: Use the protein tools at EXPASY to investigate the functional impact of polyQ peptides? Start with 6 and work up.

7. Team Workshop 4: Why is N-acetylcysteine proposed as a potential treatment for Huntington’s disease? Can you propose an alternative treatment? Use the NIH database of clinical trials to find clinical trials directed towards Huntington’s. Pick 1 or 2 and list the type of trial, the intervention, patient cohort, outcome measures etc.

8. Remember Before 12 PM of the next class day:
go to b.socrative.com/student/login and complete the quiz