1. Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma 
Fred C. Lam, Michael B. Yaffe 
Cancer Cell 
Volume 29, Issue 4, Pages (April 2016)
DOI: /j.ccell
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Single-Cell Phosphoproteomic Profiling of Treatment-Resistant Patient-Derived GBM Xenografts Reveals Early Re-wiring of Signaling Pathways without Genomic Mutations
Mice containing drug-naive patient-derived xenografts (PDX) were treated with an mTOR kinase inhibitor (mTORki). Resistant tumor cells after treatment were analyzed by immunohistochemistry and single-cell phosphoproteomic profiling with an SCBC chip, revealing re-wiring of critical signaling nodes as the mechanism of resistance. Treatment of drug-naive PDX with combination therapies that blocked these re-wired nodes effectively eliminated the development of resistance to mTOR inhibition.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2016 Elsevier Inc. Terms and Conditions