1. Clinical Trial Available
Supplemental Table 5. Available therapies and clinical trials
Gene
FDA Approved
Therapy
Off-label Therapy
Clinical Trial Available
ALK
Crizotinib, Ceritinib,
Alectinib -
NCT , NCT
APC
Celecoxib
ARID1A
NCT , NCT
BRAF
Sorafenib, Regorafenib, Trametinib, Vemurafenib, Dabrafenib, Cobimetinib
NCT , NCT , NCT
CCNE1
CDK4
Palbociclib
NCT
CDK6
NCT , NCT
CDKN2A
NCT
CTNNB1
EGFR
Afatinib, Erlotinib,
Gefitinib, Osimertinib
Lapatinib, Panitumumab, Gefitinib, Erlotinib, Afatinib, Necitumumab
NCT , NCT , NCT , NCT , NCT , NCT , NCT , NCT
ERBB2
Lapatinib, Trasuzumab, ado-Trasuzumab Emtansine, Pertuzumab, Afatinib
NCT , NCT
FBXW7
Temsirolimus, Everolimus
NCT
FGFR1
Pazopanib, Regorafenib, Ponatinib, Lenvatinib
GNAS
Trametinib, Cobimetinib
NCT , NCT
IDH2
Azacitidine, Decitabine
NCT
KIT
Pazopanib, Sorafenib, Sunitinib, Temsirolimus, Nilotinib, Axitinib, Regorafenib, Ponatinib, Lenvatinib, Dasatinib, Everolimus, Imatinib
KRAS
NCT , NCT , NCT , NCT , NCT
MET
Crizotinib
MPL
Ruxolitinib
MYC
NCT , NCT , NCT
NF1
Temsirolimus, Trametinib, Everolimus, Cobimetinib
NCT , NCT
PIK3CA
NCT , NCT , NCT
PTEN
PTPN11
Trametinib
NCT
STK11
Temsirolimus, Bosutinib, Dasatinib, Everolimus
TP53
NCT , NCT , NCT , NCT ,NCT , NCT , NCT , NCT , NCT