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Xeroderma Pigmentosum, XPF

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Presentation on theme: "Xeroderma Pigmentosum, XPF"— Presentation transcript:

1 Xeroderma Pigmentosum, XPF
Megan Ding

2 Xeroderma Pigmentosum (XP)

3 Xeroderma Pigmentosum Group F
XPF protein (ERCC4)

4 Nucleotide Excision Repair (NER)
ccr.coriell.org/Images/NER_main.gif

5 Human Homolog of Yeast RAD1
webpath.swmed.edu/.../Images/projects/efp21.jpg

6 XPF - ERCC1 Endonuclease
ccr.coriell.org/Images/NER_main.gif

7 Correction of XPF Sijbers et al, Cell Vol. 86, (Sept. 1996)

8 Mutation at C-terminal
Tsodikov et al, PNAS Vol. 102, No (2005).

9 Mice Knockouts e) Control and (f) Ercc1 skin-specific knockout, H&E-stained sections through back skin of chronically UVB-irradiated mice

10 Development of Cancer High levels of gene modification NER Deficiency

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