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Published byJohnathan Higgins Modified over 6 years ago
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IMPI Trial design: Participants with TB pericarditis and risk for HIV were randomized to prednisolone (n = 706) vs. placebo (n = 694) and to M. indicus pranii immunotherapy over 3 months (n = 625) vs. placebo injections (n = 625). (p = 0.66) (p = 0.81) Results Glucocorticoid stratum: Death, tamponade requiring pericardiocentesis, or constrictive pericarditis: 23.8% of the prednisolone group vs. 24.5% of the placebo group (p = 0.66) Immunotherapy stratum: Death, tamponade requiring pericardiocentesis, or constrictive pericarditis: 25.0% of the immunotherapy group vs. 24.3% of the placebo group (p = 0.81) 23.8 24.5 25.0 24.3 % % Conclusions Among participants with TB pericarditis, neither prednisolone therapy nor M. indicus pranii immunotherapy was associated with a reduction in the primary outcome Glucocorticoid stratum Immunotherapy stratum Prednisolone Immunotherapy Placebo Placebo Mayosi BM, et al. N Engl J Med 2014;371:
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