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A Prospective Randomized Trial of Buffy Coat Versus CD34-Selected Autologous Bone Marrow Support in High-Risk Breast Cancer Patients Receiving High-Dose.

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Presentation on theme: "A Prospective Randomized Trial of Buffy Coat Versus CD34-Selected Autologous Bone Marrow Support in High-Risk Breast Cancer Patients Receiving High-Dose."— Presentation transcript:

1 A Prospective Randomized Trial of Buffy Coat Versus CD34-Selected Autologous Bone Marrow Support in High-Risk Breast Cancer Patients Receiving High-Dose Chemotherapy by Elizabeth J. Shpall, C. Fred LeMaistre, Kent Holland, Edward Ball, Roy B. Jones, Rein Saral, Cindy Jacobs, Shelly Heimfeld, Ronald Berenson, and Richard Champlin Blood Volume 90(11): December 1, 1997 ©1997 by American Society of Hematology

2 Flow diagram of autologous marrow processing procedure.
Flow diagram of autologous marrow processing procedure. To remain on the study, at each step outlined, patients were required to have a minimum (min) of 3.0 × 108 total nucleated cells per kilogram patients' weight (TNC/kg) at marrow harvest, and 2.0 × 108 TNC/kg in the buffy coat fraction with 0.5 × 108 TNC/kg as a backup fraction. Elizabeth J. Shpall et al. Blood 1997;90: ©1997 by American Society of Hematology

3 The progression-free survival for patients on both arms of the study was 31% (P = .492).
Elizabeth J. Shpall et al. Blood 1997;90: ©1997 by American Society of Hematology


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