1. Xeno® IV & Esthet-X® Class V—Site A
Material: XENO IV Compared with Prime and Bond NT plus Esthet-X
Title: A Clinical Evaluation of a Self-Etch Bonding Agent For Use In the Restoration of Non-carious Cervical Lesions
Principle Investigator: Dr. Deborah Cobb
Type of Restoration: Class V
6-months results:
35 Patients; 33 Xeno IV Restorations with 34 Controls; (% alpha—highest rating): Retention (97%), Sensitivity (94%), Anatomic Form (100%), Color Match (100%), Marginal Adaptation (94%), Marginal Discoloration (97%), Secondary Caries (100%)
Summary: XENO IV provided clinically acceptable results in all the categories evaluated and was comparable to Prime & Bond NT in all categories evaluated.
Material: XENO IV Compared with Prime and Bond NT plus Esthet-X
Title: A Clinical Evaluation of a Self-Etch Bonding Agent For Use In the Restoration of Non-carious Cervical Lesions
Principle Investigator: Dr. Deborah Cobb
Type of Restoration: Class V
6-months results:
35 Patients; 33 Xeno IV Restorations with 34 Controls; (% alpha—highest rating): Retention (97%), Sensitivity (94%), Anatomic Form (100%), Color Match (100%), Marginal Adaptation (94%), Marginal Discoloration (97%), Secondary Caries (100%)
Summary: XENO IV provided clinically acceptable results in all the categories evaluated and was comparable to Prime & Bond NT in all categories evaluated.
33 Class V restorations, 1/2 year results

2. Xeno® IV & Esthet-X® Class V—Site B
Material: XENO IV & Esthet-X
Title: A Clinical Evaluation of a Self-Etching Adhesive
Principle Investigator: Dr. James Dunn
Type of Restoration: Class V
18 month results: Study complete
21 Patients; 44 Restorations; (% alpha—highest rating): Retention (100%), Sensitivity (98%), Anatomic Form (98%), Color Match (66%), Marginal Adaptation (80%), Marginal Discoloration (82%), Secondary Caries (100%), Polishability (68%), Surface Staining (100%)
Summary: XENO IV gives acceptable clinical results for parameters evaluated in both anterior and posterior class V restorations. No restorations needed repair or replacement.
Material: XENO IV & Esthet-X
Title: A Clinical Evaluation of a Self-Etching Adhesive
Principle Investigator: Dr. James Dunn
Type of Restoration: Class V
18 month results: Study complete
21 Patients; 44 Restorations; (% alpha—highest rating): Retention (100%), Sensitivity (98%), Anatomic Form (98%), Color Match (66%), Marginal Adaptation (80%), Marginal Discoloration (82%), Secondary Caries (100%), Polishability (68%), Surface Staining (100%)
Summary: XENO IV gives acceptable clinical results for parameters evaluated in both anterior and posterior class V restorations. No restorations needed repair or replacement.
44 Class V restorations, 18 month results

3. Xeno® IV & Esthet-X® Class I & II
Material: XENO IV & Esthet-X
Title: A Clinical Evaluation of a Self-Etch Bonding Agent for the Use in Posterior Composite Restorations
Principle Investigator: Dr. Hans Malmstrom
Type of Restoration: Class I and II
18-month results:
32 Patients; 49 Restorations; (% alpha—highest rating): Retention (100%), Sensitivity (97%), Gingival Index (92%-mild inflammation), Anatomic Form (100%), Color Match (100%), Marginal Adaptation (90%), Marginal Discoloration (90%), Secondary Caries (100%)
Summary: XENO IV revealed very minor changes to the restorations evaluated at baseline. This bonding agent can be used when placing posterior Class I and II composite restorations.
Material: XENO IV & Esthet-X
Title: A Clinical Evaluation of a Self-Etch Bonding Agent for the Use in Posterior Composite Restorations
Principle Investigator: Dr. Hans Malmstrom
Type of Restoration: Class I and II
18-month results:
32 Patients; 49 Restorations; (% alpha—highest rating): Retention (100%), Sensitivity (97%), Gingival Index (92%-mild inflammation), Anatomic Form (100%), Color Match (100%), Marginal Adaptation (90%), Marginal Discoloration (90%), Secondary Caries (100%)
Summary: XENO IV revealed very minor changes to the restorations evaluated at baseline. This bonding agent can be used when placing posterior Class I and II composite restorations.
49 Class I & II restorations, 18 month results

4. Xeno® IV & Calibra® Indirect; Crown/Onlay
Material: XENO IV and Self-Cure Activator with Calibra
Title: A Clinical Evaluation of an Adhesive for Bonding Indirect Restorations
Principle Investigator: Dr. Jeff Blank
Type of Restoration: Indirect all ceramic crowns and onlays
1 year results:
16 Patients; 21 Restorations; (16 crowns, 5 onlays; % alpha—highest rating): Restoration Integrity (95%), Sensitivity (100%), Gingival Index (85%), Marginal Integrity (100%), Marginal Discoloration (100%), Secondary Caries (100%)
Summary: All restorations were fully seated demonstrating a low film-thickness. Xeno IV is easy to apply and does not leave a visible excess film thickness.
Material: XENO IV and Self-Cure Activator with Calibra
Title: A Clinical Evaluation of an Adhesive for Bonding Indirect Restorations
Principle Investigator: Dr. Jeff Blank
Type of Restoration: Indirect all ceramic crowns and onlays
1 year results:
16 Patients; 21 Restorations; (16 crowns, 5 onlays; % alpha—highest rating): Restoration Integrity (95%), Sensitivity (100%), Gingival Index (85%), Marginal Integrity (100%), Marginal Discoloration (100%), Secondary Caries (100%)
Summary: All restorations were fully seated demonstrating a low film-thickness. Xeno IV is easy to apply and does not leave a visible excess film thickness.
21 Restorations; 1 year results

5. Xeno® IV & Calibra® Indirect; Crown/Inlay/Onlay
Title: A Clinical Evaluation of an Adhesive for Bonding Indirect Restorations
Principle Investigator: Dr. Peter Yaman
Type of Restoration: Indirect; crowns/inlays/onlays of non-reinforced porcelain
2-year results: 23 Patients; 31 Restorations (13 crowns, 18 inlays/onlays); (% alpha—highest rating): Retention (100%), Sensitivity (88%), Gingival Index (81 %), Color Match (100%), Marginal Integrity (87%), Margin Discoloration (100%), Secondary Caries (100%)
Summary: At the two-year recall, XENO IV and SCA resulted in clinically acceptable restorations in molar and pre-molar teeth with very minor clinical complications.
Title: A Clinical Evaluation of an Adhesive for Bonding Indirect Restorations
Principle Investigator: Dr. Peter Yaman
Type of Restoration: Indirect; crowns/inlays/onlays of non-reinforced porcelain
1-year results: 26 Patients; 35 Restorations (16 crowns, 19 inlays/onlays); (% alpha—highest rating): Restoration (97%), Sensitivity (84%), Gingival Index (76 %), Color Match (100%), Marginal Integrity (91%), Margin Discoloration (100%), Secondary Caries (100%)
Summary: At the one-year recall, XENO IV and SCA resulted in clinically acceptable restorations in molar and pre-molar teeth with very minor clinical complications.
31 Restorations; 2 year results

6. Xeno® IV--Retention Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 2-year results: 31 Restorations
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 1-year results: 35 Restorations

7. Xeno® IV--Sensitivity
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 2-year results: 31 Restorations
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 1-year results: 35 Restorations

8. Xeno® IV--Marginal Discoloration
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 2-year results: 31 Restorations
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 1-year results: 35 Restorations

9. Xeno® IV--Secondary Caries
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 2-year results: 31 Restorations
Material: XENO IV—Direct Composite Restorations
Principle Investigator: Dr. Deborah Cobb,Type of Restoration: Class V, 6-months results: 33 Restorations
Principle Investigator: Dr. James Dunn Type of Restoration: Class V 1-year results: 40 Restorations
Principle Investigator: Dr. Hans Malmstrom Type of Restoration: Class I and II, 18-month results: 49 Restorations
Material: XENO IV—Indirect Restorations
Principle Investigator: Dr. Jeff Blank, Type of Restoration: Indirect, 1 year results: 21 Restorations
Principle Investigator: Dr. Peter Yaman, Type of Restoration: Indirect; crowns/inlays/onlays, 1-year results: 35 Restorations