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Volume 148, Issue 1, Pages e3 (January 2015)

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1 Volume 148, Issue 1, Pages 52-63.e3 (January 2015)
Development of the Lémann Index to Assess Digestive Tract Damage in Patients With Crohn's Disease  Benjamin Pariente, Jean-Yves Mary, Silvio Danese, Yehuda Chowers, Peter De Cruz, Geert D’Haens, Edward V. Loftus, Edouard Louis, Julian Panés, Jürgen Schölmerich, Stefan Schreiber, Maurizio Vecchi, Julien Branche, David Bruining, Gionata Fiorino, Matthias Herzog, Michael A. Kamm, Amir Klein, Maïté Lewin, Paul Meunier, Ingrid Ordas, Ulrike Strauch, Gian-Eugenio Tontini, Anne-Marie Zagdanski, Cristiana Bonifacio, Jordi Rimola, Maria Nachury, Christophe Leroy, William Sandborn, Jean-Frédéric Colombel, Jacques Cosnes  Gastroenterology  Volume 148, Issue 1, Pages e3 (January 2015) DOI: /j.gastro Copyright © 2015 AGA Institute Terms and Conditions

2 Figure 1 Scatterplot of the predicted indexes as a function of the investigator damage evaluations. (A) Organ indexes vs organ damage evaluation calculated from investigators’ segmental damage evaluations. (B) Global index vs investigator global damage evaluation. For small bowel, 2 patients with a very high or a high level of damage (investigator calculated damage evaluation of 77 and 41.5) were not shown in the (A) (it should be noted that the results of the multiple linear mixed model were quite similar when taking into account these 2 patients or not). Predicted indexes were estimated from the multiple linear mixed model. The area of each circle is proportional to the number of coincident data plotted there. r is the unbiased estimate of the correlation coefficient between predicted organ (and global) damage indexes and investigator organ- (and global) damage evaluations, derived from the internal cross-validation procedure, using bootstrap method. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

3 Figure 2 Boxplot of Lémann Index according to disease duration. Box reflects the median, first, and third quartiles, and whiskers the 95% CI. Lémann Index was calculated using the final coefficients (see Table 4). Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

4 Supplementary Figure 1 Subject disposition.
Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

5 Supplementary Figure 2 Scatterplot of the standardized residuals as a function of the predicted organ indexes. The area of each circle is proportional to the number of coincident data plotted there. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

6 Supplementary Figure 3 Scatterplot of the standardized residuals as a function of the predicted global index. The area of each circle is proportional to the number of coincident data plotted there. Gastroenterology  , e3DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions


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