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Effect of pressure management during hypothermic selective cerebral perfusion on cerebral hemodynamics and metabolism in pigs  Peter L. Haldenwang, MD,

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Presentation on theme: "Effect of pressure management during hypothermic selective cerebral perfusion on cerebral hemodynamics and metabolism in pigs  Peter L. Haldenwang, MD,"— Presentation transcript:

1 Effect of pressure management during hypothermic selective cerebral perfusion on cerebral hemodynamics and metabolism in pigs  Peter L. Haldenwang, MD, Justus T. Strauch, MD, Katharina Müllem, Hannah Reiter, Oliver Liakopoulos, MD, Jürgen H. Fischer, MD, Hildegard Christ, Thorsten Wahlers, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 139, Issue 6, Pages (June 2010) DOI: /j.jtcvs Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Cardiopulmonary bypass assessment. P, Arterial pressure measurement/reference microsphere withdrawal; SCP, selective cerebral perfusion, PO, microsphere injection; Ao, aorta; RA, right atrium; Res, reservoir; LV, left ventricle; LV vent, left ventricular vent cannulation; Ox, oxygenator. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Study protocol, showing time points at which measurements cited in the table and figures were taken. Microsphere injections are marked with asterisks. Details are listed in the text. The 3 groups differ, beginning with time point 3 (5minutes of SCP). MAP, Mean arterial pressure; CPB, cardiopulmonary bypass; SCP, selective cerebral perfusion; HCA, hypothermic circulatory arrest; T, temperature. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Time course of global cerebral blood flow (CBF) over the entire experiment. Values are shown as mean values ± standard errors. ∗Significant differences between groups at a time point value (p). ∗∗Significant differences in change from baseline (pΔ). SCP, Selective cerebral perfusion; T, temperature. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Time course of regional cerebral blood flow (RBF) in the neocortex, cerebellum, pons, and the hippocampus region. Values are shown as mean values. ∗Significant differences between groups at a time point. SCP, Selective cerebral perfusion. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Time course of cerebral metabolic rate (CMRO2) over the entire experiment. Values are shown as means ± standard errors. SCP, Selective cerebral perfusion; T, temperature. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

7 Figure 6 Time course of intracerebral pressure (ICP) over the entire experiment. Values are shown as means ± standard errors. ∗Significant differences between groups at a time point value (p). SCP, Selective cerebral perfusion; T, temperature. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions


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