1. Translational Informatics Applied to Drug Safety (TrIADS)
Richard D. Boyce, PhD
Assistant Professor
Department of Biomedical Informatics
University of Pittsburgh
Faculty, Center for Pharmaceutical Policy and Prescribing
Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program

2. A new paradigm for drug-drug interaction evidence and knowledge
NLM R01LM011838
Dynamic enhancements
Scientific literature
Product labeling
Semantic annotation pipeline
Aim 1
Knowledge curation
A framework for representing PDDI assertions and evidence as interoperable Linked Data available for community annotation
Data driven:
Synthesis of public PDDI sources
Expert:
Web-based scientific discourse
Aim 2
Aim 3
More efficient synthesis of PDDI evidence, easier identification of gaps
Reduced risk of a PDDI medication error!
Expected benefits:
More complete and accurate PDDI evidence
Better informed pharmacists and other clinicians
More effective PDDI alerting and decisions support systems

3. Interventions that improve drug safety for older adults
NIA K01AG044433
Automated
Observational Health Data Sciences and Informatics (OHDSI) LAERTES project
Patient Specific
Actionable

4. Research and Clinical Impact
Google scholar h-index: 10
Selected Publication
Boyce RD, Collins C, Horn J, Kalet I. Computing with evidence part II: an evidential approach to predicting metabolic drug-drug interactions, Journal of Biomedical Informatics, 2009 Dec;42(6): PMCID : PMC
Boyce RD, Horn JR, Hassanzadeh O, de Waard A, Schneider J, Luciano JS, Rastegar-Mojarad M, Liakata M. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness. J Biomed Semantics Jan 26;4(1):5. DOI / PMID: PMCID – PMC
Boyce. RD., Ryan. PB., Noren. N., et al., Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest. Drug Safety Volume 37, Issue 8 (2014), Page DOI: /s , PubMed PMID: PMCID: PMC
Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD, Toward a complete dataset of drug-drug interaction information from publicly available sources, Journal of Biomedical Informatics. 55 (2015), DOI: /j.jbi PMCID: PMC
Inventions
“Pharmacogenomics Information System”, University of Pittsburgh Invention Disclosure Number
“An automated multifactorial patient-specific fall risk intervention designed for the nursing home setting that includes consideration of potential drug-drug interactions”, University of Pittsburgh Invention Disclosure Number: