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Friday NOTES: Mutations
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(1) Mutations Mutation: Change in nitrogenous base sequence of DNA.
TYPES: Deletion Insertion Point
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(2) Deletions Deletion: Removal of 1 or more nitrogenous bases.
Screws up triplet code frameshift Will impact ability to make that protein. Example: Originally AUGUUUCCUCAGUGA Met-Phe-Pro-Gln-Stop Mutation AUUUUCCUCAGUGA Ile-Phe-Leu-Ser-GA???
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(3) Insertion Deletion: Addition of 1 or more nitrogenous bases.
Screws up triplet code frameshift Will impact ability to make that protein. Example: Originally AUGUUUCCUCAGUGA Met-Phe-Pro-Gln-Stop Mutation AUGACUUUCCUCAGUGA Met-Thr-Phe-Leu-Ser-GA???
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(4) Point Mutation Deletion: Change in 1 nitrogenous base.
Maintains triplet code. May or May Not impact ability to make that protein. Example: Originally AUGUUUCCUCAGUGA Met-Phe-Pro-Gln-Stop Mutation #1 AUGUUACCUCAGUGA Mutation #2 AUGUAUCCUCAGUGA Met-Tyr-Pro-Gln-Stop
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(5) Consequences Positive (+) Negative (-)
Main reason for variation and diversity! Huge driving force behind evolution! Could be beneficial to organism and population! May have no effect at all! May hinder the production of a protein. Could cause a disorder or disease. Could kill an organism. Could cause cancer.
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