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Volume 161, Issue 6, Pages (June 2015)

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1 Volume 161, Issue 6, Pages 1252-1265 (June 2015)
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes  Stuart L. Schreiber, Joanne D. Kotz, Min Li, Jeffrey Aubé, Christopher P. Austin, John C. Reed, Hugh Rosen, E. Lucile White, Larry A. Sklar, Craig W. Lindsley, Benjamin R. Alexander, Joshua A. Bittker, Paul A. Clemons, Andrea de Souza, Michael A. Foley, Michelle Palmer, Alykhan F. Shamji, Mathias J. Wawer, Owen McManus, Meng Wu, Beiyan Zou, Haibo Yu, Jennifer E. Golden, Frank J. Schoenen, Anton Simeonov, Ajit Jadhav, Michael R. Jackson, Anthony B. Pinkerton, Thomas D.Y. Chung, Patrick R. Griffin, Benjamin F. Cravatt, Peter S. Hodder, William R. Roush, Edward Roberts, Dong-Hoon Chung, Colleen B. Jonsson, James W. Noah, William E. Severson, Subramaniam Ananthan, Bruce Edwards, Tudor I. Oprea, P. Jeffrey Conn, Corey R. Hopkins, Michael R. Wood, Shaun R. Stauffer, Kyle A. Emmitte Linda S. Brady, Jamie Driscoll, Ingrid Y. Li, Carson R. Loomis, Ronald N. Margolis, Enrique Michelotti, Mary E. Perry, Ajay Pillai, Yong Yao Stuart L. Schreiber, Joanne D. Kotz, Min Li, Jeffrey Aubé, Christopher P. Austin, John C. Reed, Hugh Rosen, E. Lucile White, Larry A. Sklar, Craig W. Lindsley, Benjamin R. Alexander, Joshua A. Bittker, Paul A. Clemons, Andrea de Souza, Michael A. Foley, Michelle Palmer, Alykhan F. Shamji, Mathias J. Wawer, Owen McManus, Meng Wu, Beiyan Zou, Haibo Yu, Jennifer E. Golden, Frank J. Schoenen, Anton Simeonov, Ajit Jadhav, Michael R. Jackson, Anthony B. Pinkerton, Thomas D.Y. Chung, Patrick R. Griffin, Benjamin F. Cravatt, Peter S. Hodder, William R. Roush, Edward Roberts, Dong-Hoon Chung, Colleen B. Jonsson, James W. Noah, William E. Severson, Subramaniam Ananthan, Bruce Edwards, Tudor I. Oprea, P. Jeffrey Conn, Corey R. Hopkins, Michael R. Wood, Shaun R. Stauffer, Kyle A. Emmitte Linda S. Brady, Jamie Driscoll, Ingrid Y. Li, Carson R. Loomis, Ronald N. Margolis, Enrique Michelotti, Mary E. Perry, Ajay Pillai, Yong Yao  Cell  Volume 161, Issue 6, Pages (June 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Centers Comprising the MLPCN Network
Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Figure 2 Spectrum of Targets Modulated by MLP Probes
Target classes modulated by MLP probes are visualized based on HTS data and user-defined thresholds. Arc lengths represent the number of distinct targets within a target class that are modulated by this collection of probes. This graph was generated using the BioAssay Research Database (BARD; bard.nih.gov), which was generated by the MLP to enable users to mine and visualize small-molecule activity data. The graph depicts the bioactivity of about 65% of the total number of MLP probes across 415 unique assays associated with 460 targets, which were categorized using the Panther database into 110 protein categories. The breadth of target classes highlights the diverse biology and target space explored by the MLP. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

4 Figure 3 MLP Probes Highlighted in Vignettes
Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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