1. NovaMouseTM Sherazad Mahomedally Nicole Serago Pooja Shah Advisors:
Bob Allen
Ben Schnitz

2. Significance of Mice Increasing use in research
Transgenic and Breeding capabilities
Miniature size
Low maintenance cost

3. Problem to be Solved No desirable method of measurement Miniature size
Difficulty with physiological measurements

4. Why pulse oximetry? Measure blood oxygen saturation Measure heart rate
Monitoring during surgery
Research on free ranging mice

5. Why NovaMouseTM?
Survival of mice
Reduction of cost
Less expensive

6. Specific Goals To build a pulse oximeter for a mouse: Small size
Ability to be wireless
Allows movement
Accurate
Reaching heart rates up to 800 beats per minute

7. Current Design Nonin Medical, Inc. Pros: Cons: Allows movement
For large animals
Inaccurate
Not wireless

8. Our Design Reduced hemoglobin vs. oxyhemoglobin
DC and pulsatile components
Ratio of ratios

9. Design Specifications
Frequency range: 0.1 Hz to 150 Hz
Op Amp: 2.3V to 5.5V supply
Rechargeable Battery: 4.8V
LED: 1.7V supply
Gain: 10
Tail dimensions

10. Circuit Transimpedance Amplifier High Pass Filter
Two Pole Low Pass Filter
Low Pass Filter

11. Problems Encountered/ Solutions
Found new LED’s with common input voltage of 1.7V
Used wrist straps carefully
Incompatible red and infrared LED voltage ranges
Red LED: 1.8V to 4V
Infrared LED: 1V to 1.5V
Blown out op amps due to static electricity

12. Market Potential and Budget
Universities, hospitals, and other research facilities
50,000 devices in the year 2004
About 1 million mice are potential targets
$5-10 million in sales
$100 in expenses to date

13. Status