1. Updates in the Clinical Science of CGRP Antagonism for the Treatment of Migraine

3. Introduction Migraine

4. Introduction Migraine Treatments

5. What Is CGRP?

6. Function of CGRP

7. CGRP Pathophysiology Effect of Infusion of hα-CGRP

8. Small Molecules (Gepants) vs mAbs

9. Initial CGRP Antagonists (Gepants)

10. Other CGRP Antagonists (Gepants)

11. Ubrogepant Trial Design and Results

12. Clinical Implications of Small Molecule CGRP Antagonists Gepants

13. Gepants vs Triptans

14. mAbs

15. Immunogenicity Potential for mAbs

16. CGRP mAbs

17. ALD403 Study Design

18. ALD403 Study Results

19. Galcanezumab Study Design

20. Galcanezumab Study Results

21. TEV Study Design

22. TEV Study Results

23. TEV Study Design

24. TEV-48125 Post Hoc Analysis in Chronic Migraine

25. Erenumab Study Design and Results in Episodic Migraine

26. Erenumab Study Design in Chronic Migraine

27. Erenumab Study Results in Chronic Migraine

28. Summary mAbs

29. Breakthrough Headache

30. Triptan Targets

31. Potential but Unknown Cardiovascular and Cerebrovascular Risks With CGRP Blockade

32. GCRP Receptor Complex

33. Conclusions

34. Abbreviations