1. EXERCISE
1.MUSCLE B:LOOD FLOW
2.CARDIAC OUTPUT
3.BLOOD PRESSURE

2. MUSCULAR BLOOD FLOW 1.BLOOD FLOW DURING EXERCISE
2.CIRCULATORY REAJUSTMENT DURING EXERCISE
3.EFFECTS OF MASS SYMPATHETIC DISCHARGE

3. CADIAC OUTPUT 1.MEAN CIRCULATORY FILLING PRESSURE
2.DECREASE THE RESISTANCE IN THE ACTIVE MUSCLES

4. BLOOD FLOW DURING EXERCISE

5. BLOOD PTRESSURE
P = F x R

6. CORONARY CIRCULATION

7. Normal coronary blood flow
The resting coronary blood flow= 225 ml/min
In strenuous exercise = increase three to four folds.

8. CORONARY BLOOD FLOW DURING CARDIAC CYCLE

9. Epicardial Vs. subendocardial blood flow

10. Control of coronary blood flow
Metabolic regulation
Nervous control

11. Increased contraction
Metabolic regulation
Blood flow through coronary system is regulated almost entirely by local arterial vasodilatation in response to cardiac muscle need for nutrients.
Increased contraction
Increase in rate of coronary blood flow

12. METABOLIC REGULATION Oxygen demand. Vasodilator substances: Adenosine.
Potassium ions.
Hydrogen ions.
Carbon dioxide.
Bradykinin.
Prostaglandins.

13. Sympathetic transmitter
Nervous control
Direct effect:
Direct action of Ach and Nepi on coronary vessels.
Sympathetic transmitter
Vascular dilatation
β receptors
Vascular constriction
α receptors

14. NERVOUS CONTROL Indirect effect: Symp stimulation HR & contractility
Rate of metabolism.
activity local blood flow regulatory mechanisms blood flow increases.