1. Thickening of intima (atherosclerotic plaque) due to proliferation of cholesterol-containing macrophages and other cells
Thrombus formed due to atherosclerotic plaque rupture
Atherosclerosis is the most common cause of CAD (IHD) and CAD is the most common cause of death worldwide

2. Red infarction of lung

4. Adenoma with low grade dysplasia
Stratification of nuclei
Hyperchromasia
Cigar-shaped nuclei (high N/C ratio)
Goblet cell depletion
Mild architecture disturbance
Normal colonic mucosa
polyp

5. The basement membrane is still intact but the dysplasia is high grade (squamous cell carcinoma in situ)
= high grade dysplasia
Dysplastic epithelium
The dysplasia is in the 3 layers from bottom
to top
Dysplasia here:
Loss of polarity of cells and
loss of maturation
Hyperchromasia
Nuclear pleomorphism
Enlarged nuclei
High mitoses (not limited
To basal layer)
Normal squamous epithelium with maturation (from basal columnar layer to superficial squamous cells)
These are inflammatory cells (not invasion)

6. Invasive squamous cell carcinoma
Keratin pearls…which means that there is some degree of differentiation
Tongues & islands of malignant squamous cells

7. Anaplasia

8. Abnormal mitosis in a background of severe atypia
Chromatin clumps

9. High atypia
mitosis

10. mitoses

11. Malignant tumor
Prominent nucleolus

12. Colonic adenocarcinoma
Malignant glands (severe dysplasia with severe disturbance in architecture)
…in submucosa……………invasion
Colonic adenocarcinoma
Muscularis mucosae

13. Poorly differentiated tumor

14. Basal Cell carcinoma Islands of basaloid cells
Peripheral palisading of cells at the periphery of each island