1. Tianfang Li
Quantitative Reconstruction for Brain SPECT with Fan-Beam Collimators
Nov. 24th, 2003
SPECT system: *
Non-uniform attenuation
Detector response or
point spread function (PSF) •
Scatter
Poisson noise
Developing a fast and accurate reconstruction algorithm for single photon emission computed tomography (SPECT)
Compensates for Poisson noise, Compton scatter, collimator/detector response, and attenuation effects
Quantitative analysis with regional bias-variance plot, receiver operating characteristic (ROC) study, and Hotelling trace calculation
Verified with Monte Carlo simulations and compared with the widely used ordered-subset expectation maximization (OSEM) algorithm. Similar image quality is achieved with computational cost improved about 48 times.
Filtered backprojection (FBP) reconstruction
Original phantom
OSEM reconstruction
Reconstruction with proposed method