1. Cancer Metabolism: A New Treatment Approach

3. Program Goals

4. Overview

5. History of Cancer Metabolism

6. Abnormal Metabolic Pathways in Cancer

7. Sources of ATP Energy for Normal and Malignant Cells Under Varied Oxygenation

8. Role of Oncogenes and Tumor Suppressor Genes

9. Overexpression of c-MYC in Cancer

10. Targeting Glycolysis in Cancer

11. Hereditary Syndromes

12. Role of TET2 in DNA Methylation

13. TET2 Mutation in Hematologic Malignancies

14. TET2 Mutations Are Prevalent in Healthy Older Adults

15. IDH Mutations in Cancer

16. IDH Mutations in Cancer Development

17. IDH Mutations Cause an Oncometabolic Gain-of-Function

18. Targeting IDH Metabolically

19. IDH Mutations in Myeloid Malignancies

20. Frequency of IDH Mutations in Different Cancer Types

21. 2-HG as Therapeutic Target and Tumor Biomarker

22. IDH Inhibition in Cancer Proof of Principle

23. IDH Inhibition in Cancer Principle to Practice

24. Conclusions

25. Abbreviations