1. Introduction to the AOP-Wiki
Global AOP Network
>130 AOPs (user defined)
>750 KEs
>1000 KERs
≈3500 emergent

2. https://training.aopwiki.org Aopwiki.org KE Pages KE Pages AOP Page
Description
Measurement/ detection
Domain of applicability
AOP Page
KER Pages
Title
Description
Biological plausibility
Empirical support
Inconsistencies and uncertainties
Quantitative understanding
Aopwiki.org

3. State of the AOP-Wiki Global AOP Network >130 AOPs (user defined)
>750 KEs
>1000 KERs
≈3500 emergent Paths

5. Querticin

6. A Hazard Narrative, Supported by Evidence

8. TPO inhibition DIO1 inhibition DIO2 inhibition
IYD inhibition
TH in neural tissues, decreased
Hippocampal anatomy, altered
Hippocampal function, decreased
Cognitive function, decreased
NIS inhibition
Iodide in thyroid, decreased
TPO inhibition
TH synthesis, decreased
T4 in serum, decreased
T4 in tissue, decreased
Metamorphosis, impaired
Survival, reduced
DIO1 inhibition
T3 in tissue, decreased
Anterior SB inflation, impaired
Hearing, reduced
DIO2 inhibition
y.o.y survival, reduced
Population trajectory, decreased
Posterior SB inflation, impaired
Swimming performance, reduced

9. Conserved biology that readily extrapolates across taxa
Predicted taxa-specific hazards

10. User name: author@epa.gov Password: AOPtraining4@!!
So, you’d like to be an AOP Developer……
Part 2.
Objective: Gain hands on experience searching the AOP-Wiki and creating a new AOP (including linking to existing KEs, KERs, where relevant).
Follow along as we demonstrate the entry of the AOP defined in exercise 1 into the AOP-Wiki.
User name:
Password:

11. Accessing the AOP-Wiki
Open to anyone, no account required
Read access
Create account, no approvals required
Commenting
Create account
Submit brief developer application for approval
Development/write access

12. User name: author@epa.gov Password: AOPtraining4@!!
User name:
Password: