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TZD enhances cisplatin sensitivity through suppression of endotrophin‐mediated EMT, fibrosis and angiogenesis.A,B.Schematic diagram for allografts (A),

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Presentation on theme: "TZD enhances cisplatin sensitivity through suppression of endotrophin‐mediated EMT, fibrosis and angiogenesis.A,B.Schematic diagram for allografts (A),"— Presentation transcript:

1 TZD enhances cisplatin sensitivity through suppression of endotrophin‐mediated EMT, fibrosis and angiogenesis.A,B.Schematic diagram for allografts (A), indicating cancer cells were isolated from tumours in PyMT (Ctrl) and PyMT/endotrophin (ETP) mice and implanted into wild‐type hosts (0.5 × 106 cells/mouse). TZD enhances cisplatin sensitivity through suppression of endotrophin‐mediated EMT, fibrosis and angiogenesis.A,B.Schematic diagram for allografts (A), indicating cancer cells were isolated from tumours in PyMT (Ctrl) and PyMT/endotrophin (ETP) mice and implanted into wild‐type hosts (0.5 × 106 cells/mouse). Host mice were given TZD (20 mg/kg) or ND diet at 10 days before implantation for tumour progression. Cisplatin (1 mg/kg, ip., every 5 days) was administered at 3‐weeks post‐implantation. Quantification of tumour volume (B), showing TZD suppressed tumour growth in endotrophin+‐tumours. Data represent mean ± SD (n = 8–9/group). *p = 0.05, **p = 0.01 and ***p = 0.001 Ctrl/ND versus ETP/ND; ##p = 0.01 and ###p = 0.001 ETP/ND versus ETP/TZD by unpaired Student's t‐test.C–F.Histological analysis of tumours in allografts after cisplatin treatment. H&E staining and necrotic area quantification (C), showing significantly increased chemo‐sensitivity in endotrophin+ tumours upon combination of TZD with cisplatin. Necrotic area (*). ***p <  and ##p =  Vimentin staining quantification (D), showing decreased EMT in both Ctrl‐ and endotrophin+‐tumours by TZD. ***p <  and ###p <  Quantification of perfused lectin staining (E), showing the increased functional blood vessels in endotrophin+‐tumours was decreased by TZD. *p = 0.015, **p = 0.001 and ##p =  Masson's Trichrome C staining quantification (F), showing increased fibrosis in endotrophin+‐tumours was decreased by TZD. ***p <  and ##p =  Scales: 200 µm (A), 100 µm (D–E) and 50 µm (F). Statistics (*Ctrl/ND/CIS vs. Ctrl/TZD/CIS or ETP/ND/CIS; #ETP/ND/CIS vs. ETP/TZD/CIS) were analysed by unpaired Student's t‐test. Jiyoung Park et al. EMBO Mol Med. 2013;5: © as stated in the article, figure or figure legend

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